Document Detail


Adaptation of upper airway muscles to chronic endurance exercise.
MedLine Citation:
PMID:  12153959     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We tested the hypothesis that chronic endurance exercise is associated with the recruitment of four major upper airway muscles (genioglossus, digastric, sternohyoid, and omohyoid) and results in an increased oxidative capacity and a fast-toward-slow shift in myosin heavy chain (MHC) isoforms of these muscles. Female Sprague-Dawley rats (n = 8; 60 days old) performed treadmill exercises for 12 weeks (4 days/week; 90 minutes/day). Age-matched sedentary female rats (n = 10) served as control animals. Training was associated with an increase (p < 0.05) in the activities of both citrate synthase and superoxide dismutase in the digastric and sternohyoid muscles, as well as in the costal diaphragm. Compared with the control animals, Type I MHC content increased (p < 0.05) and Type IIb MHC content decreased (p < 0.05) in the digastric, sternohyoid, and diaphragm muscles of exercised animals. Training did not alter (p > 0.05) MHC phenotype, oxidative capacity, or antioxidant enzyme activity in the omohyoid or genioglossus muscle. These data indicate that endurance exercise training is associated with a fast-to-slow shift in MHC phenotype together with an increase in both oxidative and antioxidant capacity in selected upper airway muscles. It seems possible that this exercise-mediated adaptation is related to the recruitment of these muscles as stabilizers of the upper airway.
Authors:
Heather K Vincent; Robert A Shanely; Darby J Stewart; Haydar A Demirel; Karyn L Hamilton; Andrew D Ray; Charles Michlin; Gaspar A Farkas; Scott K Powers
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  166     ISSN:  1073-449X     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-08-02     Completed Date:  2002-08-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  287-93     Citation Subset:  AIM; IM    
Affiliation:
Department of Exercise and Sport Sciences, Center for Exercise Science, University of Florida, Gainesville, FL 32611, USA.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological / genetics,  physiology*
Animals
Antioxidants / metabolism
Exercise Test
Female
Lipid Peroxidation / genetics,  physiology
Models, Animal
Myosin Heavy Chains / genetics,  metabolism
Oxidation-Reduction
Phenotype
Physical Conditioning, Animal / physiology*
Physical Endurance / genetics,  physiology*
Rats
Rats, Sprague-Dawley
Respiratory Muscles / metabolism*
Respiratory System / metabolism
Time Factors
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Myosin Heavy Chains

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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