Document Detail

Adaptation to periodic high-altitude hypoxia inhibits baroreflex vagal bradycardia in rats.
MedLine Citation:
PMID:  10977907     Owner:  NLM     Status:  MEDLINE    
A 3-week course of adaptation to high-altitude hypoxia (4500 m above sea level) inhibited baroreflex vagal bradycardia induced by a rapid rise of systemic blood pressure in conscious rats. Bradycardic responses to electrical stimulation of peripheral end of the right vagus nerve and methacholine (M(2) muscarinic receptor agonist) in hypoxia-adapted rats did not differ from the control. It is concluded that hypoxia inhibits baroreflex vagal bradycardia by acting on a central element of the baroreceptor reflex arch.
M N Obrezchikova; O S Tarasova; A S Borovik; V B Koshelev
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  129     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2001-01-26     Completed Date:  2001-08-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  327-9     Citation Subset:  IM    
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University.
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MeSH Terms
Adaptation, Physiological*
Anoxia / physiopathology*
Bradycardia / physiopathology*

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