| Adaptation to extreme stress: post-traumatic stress disorder, neuropeptide Y and metabolic syndrome. | |
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MedLine Citation:
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PMID: 20881319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The prevalence rates of obesity and metabolic syndrome are on the rise in the United States. Epidemiological surveys suggest that the rates of these medical conditions are especially high among persons with psychiatric disorders, including post-traumatic stress disorder (PTSD). A variety of factors are thought to contribute to the risk for metabolic syndrome, including excessive caloric intake, decreased activity and energy expenditure, use of certain medications, stress and genetic influences. Recent research demonstrates that stress, acting through the neuropeptide Y (NPY) and glucocorticoid systems, potentiates the development of obesity and other aspects of metabolic syndrome in mice fed a high caloric, fat and sugar diet. Alterations in the NPY and glucocorticoid systems also impact behavioral adaptation to stress, as indicated by studies in animals and persons exposed to severe, life-threatening or traumatic stress. The following review examines the biology of the NPY and neuroactive steroid systems as physiological links between metabolic syndrome and PTSD, a paradigmatic neuropsychiatric stress disorder. Hopefully, understanding the function of these systems from both a translational and systems biology point of view in relation to stress will enable development of more effective methods for preventing and treating the negative physical and mental health consequences of stress. |
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Authors:
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Ann M Rasmusson; Paula P Schnurr; Zofia Zukowska; Erica Scioli; Daniel E Forman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Experimental biology and medicine (Maywood, N.J.) Volume: 235 ISSN: 1535-3699 ISO Abbreviation: Exp. Biol. Med. (Maywood) Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-30 Completed Date: 2010-10-28 Revised Date: 2011-03-11 |
Medline Journal Info:
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Nlm Unique ID: 100973463 Medline TA: Exp Biol Med (Maywood) Country: England |
Other Details:
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Languages: eng Pagination: 1150-62 Citation Subset: IM |
Affiliation:
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VA Boston Healthcare System, Boston, MA 02130, USA. ann.rasmusson@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Animals Dehydroepiandrosterone / physiology Female Glucocorticoids / physiology Humans Hydrocortisone / physiology Male Metabolic Syndrome X / etiology*, physiopathology Mice Models, Biological Neuropeptide Y / genetics, physiology* Pregnanolone / physiology Risk Factors Stress Disorders, Post-Traumatic / complications*, genetics, physiopathology Stress, Physiological Testosterone / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL055310/HL/NHLBI NIH HHS; HL067357/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Neuropeptide Y; 128-20-1/Pregnanolone; 50-23-7/Hydrocortisone; 53-43-0/Dehydroepiandrosterone; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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