Document Detail

Adaptation of molecular circadian clockwork to environmental changes: a role for alternative splicing and miRNAs.
MedLine Citation:
PMID:  23825200     Owner:  NLM     Status:  MEDLINE    
Circadian (24 h) clocks provide a source of internal timing in most living organisms. These clocks keep time by using complex transcriptional/post-translational feedback loops that are strikingly resilient to changes in environmental conditions. In the last few years, interest has increased in the role of post-transcriptional regulation of circadian clock components. Post-transcriptional control plays a prominent role in modulating rapid responses of the circadian system to environmental changes, including light, temperature and general stress and will be the focus of this review.
Osnat Bartok; Charalambos P Kyriacou; Joel Levine; Amita Sehgal; Sebastian Kadener
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-07-03
Journal Detail:
Title:  Proceedings. Biological sciences / The Royal Society     Volume:  280     ISSN:  1471-2954     ISO Abbreviation:  Proc. Biol. Sci.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-04     Completed Date:  2014-03-03     Revised Date:  2014-08-24    
Medline Journal Info:
Nlm Unique ID:  101245157     Medline TA:  Proc Biol Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  20130011     Citation Subset:  IM    
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MeSH Terms
Alternative Splicing*
Arabidopsis / genetics,  metabolism,  physiology
Circadian Clocks / genetics*,  physiology
Circadian Rhythm / genetics,  physiology
Drosophila melanogaster / genetics,  physiology
MicroRNAs / genetics,  metabolism*
Neurospora / genetics,  metabolism
Protein Processing, Post-Translational*
Grant Support
BB/H018093/1//Biotechnology and Biological Sciences Research Council; //Biotechnology and Biological Sciences Research Council; //Canadian Institutes of Health Research
Reg. No./Substance:

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