Document Detail

Adaptation of intercalated cells along the collecting duct to systemic acid/base changes.
MedLine Citation:
PMID:  21030969     Owner:  NLM     Status:  In-Process    
Collecting duct intercalated cells respond to short-term acid/base perturbations by rapidly shuttling H(+)-ATPase to and from the plasma membrane. Purkerson et al. provide information on the regulation of the anion transporters during chronic acidosis and acute recovery (alkalosis). They found that the major mechanism for both acute and chronic states is regulation of both the H(+)-ATPase and the anion exchangers plus changes in the overall expression level of these anion transporters in chronic adaptation.
John H Schwartz; Edward A Alexander
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Publication Detail:
Type:  Comment; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Kidney international     Volume:  78     ISSN:  1523-1755     ISO Abbreviation:  Kidney Int.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  949-51     Citation Subset:  IM    
Renal Section, Boston University Medical Center and Boston University School of Medicine, Boston, Massachusetts, USA.
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Comment On:
Kidney Int. 2010 Nov;78(10):993-1005   [PMID:  20592712 ]

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