Document Detail

Adaptation of insulin-resistance indicators to a repeated bout of eccentric exercise in human skeletal muscle.
MedLine Citation:
PMID:  20601735     Owner:  NLM     Status:  MEDLINE    
This study determined whether disrupted glucose and insulin responses to an oral glucose-tolerance test (OGTT) induced by eccentric exercise were attenuated after a repeated bout. Female participants (n = 10, age 24.7 +/- 3.0 yr, body mass 64.9 +/- 7.4 kg, height 1.67 +/- 0.02 m, body fat 29% +/- 2%) performed 2 bouts of downhill running (DTR 1 and DTR 2) separated by 14 d. OGTTs were administered at baseline and 48 hr after DTR 1 and DTR 2. Maximum voluntary isometric quadriceps torque (MVC), subjective soreness (100-mm visual analog scale), and serum creatine kinase (CK) were assessed pre-, post-, and 48 hr post-DTR 1 and DTR 2. Insulin and glucose area under the curve (38% +/- 8% and 21% +/- 5% increase, respectively) and peak insulin (44.1 +/- 5.1 vs. 31.6 +/- 4.0 muU/ml) and glucose (6.5 +/- 0.4 vs. 5.5 +/- 0.4 mmol/L) were elevated after DTR 1, with no increase above baseline 48 hr after DTR 2. MVC remained reduced by 9% +/- 3% 48 hr after DTR 1, recovering back to baseline 48 hr after DTR 2. Soreness was elevated to a greater degree 48 hr after DTR 1 (48 +/- 6 vs. 13 +/- 3 mm), with a tendency for greater CK responses 48 hr after DTR 1 (813 +/- 365 vs. 163 +/- 43 U/L, p = .08). A novel bout of eccentric exercise confers protective effects, with subsequent bouts failing to elicit disruptions in glucose and insulin homeostasis.
Michael S Green; J Andrew Doyle; Christopher P Ingalls; Dan Benardot; Jeffrey C Rupp; Benjamin T Corona
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International journal of sport nutrition and exercise metabolism     Volume:  20     ISSN:  1526-484X     ISO Abbreviation:  Int J Sport Nutr Exerc Metab     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-05     Completed Date:  2010-09-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100939812     Medline TA:  Int J Sport Nutr Exerc Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  181-90     Citation Subset:  IM    
Dept. of Kinesiology and Health Promotion, Troy University, Troy, AL, USA.
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MeSH Terms
Adaptation, Physiological*
Area Under Curve
Blood Glucose / metabolism
Creatine Kinase / metabolism
Exercise Test
Glucose Tolerance Test
Insulin / blood
Insulin Resistance*
Isometric Contraction / physiology
Muscle, Skeletal / physiology*,  physiopathology
Physical Exertion / physiology
Running / physiology*
Time Factors
Young Adult
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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