| Adaptation of insulin-resistance indicators to a repeated bout of eccentric exercise in human skeletal muscle. | |
| | |
MedLine Citation:
|
PMID: 20601735 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study determined whether disrupted glucose and insulin responses to an oral glucose-tolerance test (OGTT) induced by eccentric exercise were attenuated after a repeated bout. Female participants (n = 10, age 24.7 +/- 3.0 yr, body mass 64.9 +/- 7.4 kg, height 1.67 +/- 0.02 m, body fat 29% +/- 2%) performed 2 bouts of downhill running (DTR 1 and DTR 2) separated by 14 d. OGTTs were administered at baseline and 48 hr after DTR 1 and DTR 2. Maximum voluntary isometric quadriceps torque (MVC), subjective soreness (100-mm visual analog scale), and serum creatine kinase (CK) were assessed pre-, post-, and 48 hr post-DTR 1 and DTR 2. Insulin and glucose area under the curve (38% +/- 8% and 21% +/- 5% increase, respectively) and peak insulin (44.1 +/- 5.1 vs. 31.6 +/- 4.0 muU/ml) and glucose (6.5 +/- 0.4 vs. 5.5 +/- 0.4 mmol/L) were elevated after DTR 1, with no increase above baseline 48 hr after DTR 2. MVC remained reduced by 9% +/- 3% 48 hr after DTR 1, recovering back to baseline 48 hr after DTR 2. Soreness was elevated to a greater degree 48 hr after DTR 1 (48 +/- 6 vs. 13 +/- 3 mm), with a tendency for greater CK responses 48 hr after DTR 1 (813 +/- 365 vs. 163 +/- 43 U/L, p = .08). A novel bout of eccentric exercise confers protective effects, with subsequent bouts failing to elicit disruptions in glucose and insulin homeostasis. |
| | |
Authors:
|
Michael S Green; J Andrew Doyle; Christopher P Ingalls; Dan Benardot; Jeffrey C Rupp; Benjamin T Corona |
Related Documents
:
|
1526625 - Osmotic stress due to changes in plasma glucose and its regulation in iddm patients. 22704745 - Diabetic retinopathy and age-related macular degeneration in the u.s. 8299485 - Mechanism(s) of the blood glucose lowering action of benfluorex. 22702645 - Soluble cd40l in children and adolescents with type 1 diabetes: relation to microvascul... 8846685 - A study of spermatozoal motility in type 1 diabetes mellitus. 1526625 - Osmotic stress due to changes in plasma glucose and its regulation in iddm patients. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: International journal of sport nutrition and exercise metabolism Volume: 20 ISSN: 1526-484X ISO Abbreviation: Int J Sport Nutr Exerc Metab Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-07-05 Completed Date: 2010-09-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100939812 Medline TA: Int J Sport Nutr Exerc Metab Country: United States |
Other Details:
|
Languages: eng Pagination: 181-90 Citation Subset: IM |
Affiliation:
|
Dept. of Kinesiology and Health Promotion, Troy University, Troy, AL, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adaptation, Physiological* Adult Area Under Curve Blood Glucose / metabolism Creatine Kinase / metabolism Exercise Test Female Glucose Tolerance Test Humans Insulin / blood Insulin Resistance* Isometric Contraction / physiology Muscle, Skeletal / physiology*, physiopathology Physical Exertion / physiology Running / physiology* Time Factors Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 11061-68-0/Insulin; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The ?-galactosidase type A gene aglA from Aspergillus niger encodes a fully functional ?-N-acetylgal...
Next Document: The influence of caffeine and carbohydrate coingestion on simulated soccer performance.