Document Detail

Adaptation in the respiratory control system.
MedLine Citation:
PMID:  12897805     Owner:  NLM     Status:  MEDLINE    
Exposure to hypoxia, whether for short or prolonged periods or for repeated episodes, produces alterations in the ventilatory responses. This review presents evidence that these adaptations are likely to be mediated by adaptations in the respiratory chemoreflexes, particularly the peripheral chemoreflex, and proposes models of respiratory control explaining the observed changes in ventilation. After a brief introduction to the respiratory control system, a graphical model is developed that illustrates the operation of the system in the steady state, which will be used later. Next, the adaptations in ventilatory responses to hypoxia that have been observed are described, and methods of measuring the alterations in the chemoreflexes that might account for them are discussed. Finally, experimental data supporting the view that changes in the activity of the peripheral chemoreflex can account for the ventilatory adaptations to hypoxia are presented and incorporated into models of chemoreflex behaviour during exposures to hypoxia of various durations.
James Duffin; Safraaz Mahamed
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  81     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-04     Completed Date:  2004-04-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  765-73     Citation Subset:  IM    
Department of Physiology, University of Toronto, Toronto, ON M5S 1A8, Canada.
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MeSH Terms
Adaptation, Physiological / physiology*
Oxygen Consumption / physiology*
Respiratory Physiological Phenomena*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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