Document Detail

Review: Adaptation in placental nutrient supply to meet fetal growth demand: implications for programming.
MedLine Citation:
PMID:  20060581     Owner:  NLM     Status:  MEDLINE    
This review considers the hypothesis that adaptations in blood flow, exchange surface area and transporter activity enable placental supply capacity to meet fetal demand and cause alterations in fetal composition which result in life-long programming of homeostatic set points. We consider the components of placental supply capacity and describe the predominant changes each of these could impose on solute and water exchange across the placenta. We next consider the evidence that adaptations in placental nutrient supply to meet the demands of fetal growth and development do occur. Evidence from human and mouse studies suggests that adaptations occur in regulation of blood flow through the fetoplacental circulation, in exchange barrier surface area and in transporter-mediated processes for amino acids and calcium. Crucially there appear to be differences in the gestational timing of these adaptations. Finally we suggest that each of these adaptations could have separate effects on the composition of the fetus. These could affect physiological set points in different ways and so programme the lifetime responses of the individual.
Colin P Sibley; Paul Brownbill; Mark Dilworth; Jocelyn D Glazier
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-01-12
Journal Detail:
Title:  Placenta     Volume:  31 Suppl     ISSN:  1532-3102     ISO Abbreviation:  Placenta     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2010-05-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  S70-4     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Maternal and Fetal Health Research Group, School of Clinical and Laboratory Sciences, University of Manchester, Manchester Academic Health Science Centre, St Mary's Hospital, Manchester, M13 9WL, UK.
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MeSH Terms
Fetal Development / physiology
Maternal-Fetal Exchange / physiology*
Placenta / blood supply,  metabolism*
Placental Circulation / physiology
Prenatal Nutritional Physiological Phenomena / physiology*
Grant Support
//Wellcome Trust

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