| Review: Adaptation in placental nutrient supply to meet fetal growth demand: implications for programming. | |
| | |
MedLine Citation:
|
PMID: 20060581 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This review considers the hypothesis that adaptations in blood flow, exchange surface area and transporter activity enable placental supply capacity to meet fetal demand and cause alterations in fetal composition which result in life-long programming of homeostatic set points. We consider the components of placental supply capacity and describe the predominant changes each of these could impose on solute and water exchange across the placenta. We next consider the evidence that adaptations in placental nutrient supply to meet the demands of fetal growth and development do occur. Evidence from human and mouse studies suggests that adaptations occur in regulation of blood flow through the fetoplacental circulation, in exchange barrier surface area and in transporter-mediated processes for amino acids and calcium. Crucially there appear to be differences in the gestational timing of these adaptations. Finally we suggest that each of these adaptations could have separate effects on the composition of the fetus. These could affect physiological set points in different ways and so programme the lifetime responses of the individual. |
| | |
Authors:
|
Colin P Sibley; Paul Brownbill; Mark Dilworth; Jocelyn D Glazier |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-01-12 |
Journal Detail:
|
Title: Placenta Volume: 31 Suppl ISSN: 1532-3102 ISO Abbreviation: Placenta Publication Date: 2010 Mar |
Date Detail:
|
Created Date: 2010-02-22 Completed Date: 2010-05-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8006349 Medline TA: Placenta Country: England |
Other Details:
|
Languages: eng Pagination: S70-4 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Maternal and Fetal Health Research Group, School of Clinical and Laboratory Sciences, University of Manchester, Manchester Academic Health Science Centre, St Mary's Hospital, Manchester, M13 9WL, UK. colin.sibley@manchester.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Female Fetal Development / physiology Humans Maternal-Fetal Exchange / physiology* Mice Placenta / blood supply, metabolism* Placental Circulation / physiology Pregnancy Prenatal Nutritional Physiological Phenomena / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
//Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Electroconductive hydrogels: Synthesis, characterization and biomedical applications.
Next Document: Decreased placental methylation at the H19/IGF2 imprinting control region is associated with normote...