| Adaptation in human subjects to the effects of inhaled ozone after repeated exposure. | |
| | |
MedLine Citation:
|
PMID: 453698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Single exposures to low concentrations of ozone (0.4 to 0.5 ppm) have resulted in decrements in forced vital capacity and specific airway conductance. To establish whether adaptation might occur with repeated exposure, 14 normal human subjects were exposed on 5 consecutive days to 0.4 ppm of ozone for 3 hours per day in an environmental chamber. Measurements of forced vital capacity and specific airway conductance obtained after exposure to ozone were compared to corresponding control values obtained during the previous week, when the same subjects breathed filtered air in the environmental chamber for 3 hours per day on 5 consecutive days at the same time of day. The forced vital capacity was significantly lower than the control value on the first 3 days of exposure to ozone, but there was no significant difference on the fourth and fifth days. Specific airway conductance was significantly lower than the control value on the first and second days of exposure to ozone; no significant difference was noted on the third, fourth, or final day. All subjects were symptomatic on the first and second days of exposure to ozone. Symptoms resolved thereafter, with only one subject remaining symptomatic on the final day of exposure to ozone. |
| | |
Authors:
|
B P Farrell; H D Kerr; T J Kulle; L R Sauder; J L Young |
Related Documents
:
|
12706398 - Anguilla anguilla l. liver ethoxyresorufin o-deethylation, glutathione s-transferase, e... 686848 - Physiological effects of acute passive exposure to cigarette smoke. 16269218 - Biological monitoring of experimental human exposure to hydrocarbon solvent mixtures. 11214978 - Effects of exercise and noise on auditory thresholds and distortion-product otoacoustic... 19927038 - Low-intensity exercise reduces the prevalence of hyperglycemia in type 2 diabetes. 2323118 - Radionuclide assessment of left ventricular function during dobutamine infusion in pati... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: The American review of respiratory disease Volume: 119 ISSN: 0003-0805 ISO Abbreviation: Am. Rev. Respir. Dis. Publication Date: 1979 May |
Date Detail:
|
Created Date: 1979-09-01 Completed Date: 1979-09-01 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0370523 Medline TA: Am Rev Respir Dis Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 725-30 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adaptation, Biological* Airway Resistance / drug effects Cough / chemically induced Female Humans Male Ozone / adverse effects* Physical Exertion Vital Capacity / drug effects |
| Chemical | |
Reg. No./Substance:
|
10028-15-6/Ozone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Changes in the forced expiratory spirogram in young male smokers.
Next Document: Effect of low-level exposure to ozone on arterial oxygenation in humans.