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Adaptation of glomerular forces and flows to renal injury.
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MedLine Citation:
PMID:  366924     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mechanism of glomerular ultrafiltration in normal kidneys or after renal injury is reviewed. The role of increased glomerular plasma flow in mediating increases of nephron filtration rate is evidenced under experimental conditions resulting in filtration pressure disequilibrium along glomerular capillaries. The increase of nephron filtration in hypertrophied kidneys appears to be due mainly to a rise of glomerular plasma flow and, to a smaller extent, to an increase of glomerular capillary hydrostatic pressure, the ultrafiltration coefficient remaining unchanged. In contrast, in the early phases of experimentally induced nephrotoxic serum nephritis, a decrease of the ultrafiltration coefficient was observed; nephron filtration rate, however, remained within the normal range, as a consequence of a higher hydrostatic pressure in the glomerular capillaries of the nephritic kidneys.
Authors:
B M Brenner
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Yale journal of biology and medicine     Volume:  51     ISSN:  0044-0086     ISO Abbreviation:  Yale J Biol Med     Publication Date:    1978 May-Jun
Date Detail:
Created Date:  1979-03-24     Completed Date:  1979-03-24     Revised Date:  2012-05-30    
Medline Journal Info:
Nlm Unique ID:  0417414     Medline TA:  Yale J Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  301-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Animals
Capillaries / physiology
Glomerular Filtration Rate
Hydrostatic Pressure
Kidney Diseases / physiopathology*
Kidney Glomerulus / physiology*,  physiopathology
Nephrectomy
Nephritis / physiopathology
Rats
Regional Blood Flow
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Yale J Biol Med
ISSN: 0044-0086
ISSN: 1551-4056
Article Information
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Print publication date: Season: May?Jun Year: 1978
Volume: 51 Issue: 3
First Page: 301 Last Page: 305
ID: 2595721
PubMed Id: 366924
PubMed Id: 366924

Adaptation of Glomerular Forces and Flows to Renal Injury
Barry M. Brenner



Article Categories:
  • Article
Series: Long-Term Responses to Loss of Renal Mass: Glomerular Changes.


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