Document Detail

Adaptation of cough reflex with different types of stimulation.
MedLine Citation:
PMID:  1499708     Owner:  NLM     Status:  MEDLINE    
Inhalation cough challenge has become an accepted method of investigating antitussive agents. It is, therefore, important to examine the degree of tachyphylaxis seen with repeated cough challenge. In addition, different types of challenge may reveal important differences in the neuronal pathways involved in the cough reflex. Citric acid, distilled water and capsaicin were examined to determine adaptation of the cough response during acute and long-term inhalation studies in healthy subjects. To study acute tachyphylaxis two separate one minute continuous inhalation challenges (n = 13) were performed. Long-term tachyphylaxis (n = 10) was examined using citric acid and capsaicin inhalation at 10 min intervals for 40 min, and at 4 and 6 h. Cross-tachyphylaxis to citric acid and capsaicin was examined in a separate randomized crossover study (n = 10). Highly significant adaptation occurred between the first and last 10 s of the one minute challenge with citric acid (90-100%) and distilled water (74-84%), but was less pronounced with capsaicin (37-49%, at 2 microM). Cough during the whole of the second test was significantly reduced for citric acid (50%). During long-term challenge cough was attenuated over 40 min both with citric acid (100 mM, p less than 0.05; 300 mM, p less than 0.001; 1 M, p less than 0.001) and with capsaicin (3 microM, p less than 0.01; 10, 30, 100 microM, p less than 0.001 each). With higher doses, tachyphylaxis was still present at 180 min with both citric acid (300 mM, p less than 0.05) and capsaicin (100 microM, p less than 0.008).(ABSTRACT TRUNCATED AT 250 WORDS)
A H Morice; K S Higgins; W W Yeo
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The European respiratory journal     Volume:  5     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-09-11     Completed Date:  1992-09-11     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  841-7     Citation Subset:  IM    
University Dept of Medicine & Pharmacology, Royal Hallamshire Hospital, Sheffield, UK.
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MeSH Terms
Adaptation, Physiological / physiology
Bronchial Provocation Tests / methods*
Capsaicin / diagnostic use
Citrates / diagnostic use
Citric Acid
Cough / physiopathology*
Reflex / physiology*
Tachyphylaxis / physiology*
Water / diagnostic use
Reg. No./Substance:
0/Citrates; 404-86-4/Capsaicin; 77-92-9/Citric Acid; 7732-18-5/Water
Comment In:
Eur Respir J. 1992 Nov;5(10):1296-7   [PMID:  1486981 ]

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