Document Detail

Adaptation of bacteria to the intestinal niche: probiotics and gut disorder.
MedLine Citation:
PMID:  11383587     Owner:  NLM     Status:  MEDLINE    
The gastrointestinal tract is a complex ecosystem host to a diverse and highly evolved microbial community composed of hundreds of different microbial species. The interactions that occur between this complex microbial community and the human host have become the focus of scientific research due to increases in the incidence of illnesses associated with deficient or compromised microflora (e.g., gastrointestinal tract infections, inflammatory bowel disease (Crohn's disease and ulcerative colitis), irritable bowel syndrome, antibiotic-induced diarrhea, constipation, food allergies, cardiovascular disease, and certain cancers). Effective multidisciplinary research programs now complement conventional microbiology with molecular ecology techniques to provide culture-independent analysis of the gastrointestinal ecosystem. Furthermore, as we acquire an understanding of gut microflora composition and processes such as intestinal adherence, colonization, translocation, and immunomodulation, we are also elucidating mechanisms by which these can be influenced. This knowledge not only allows scientists to define the activities and interactions of "functional food"-borne beneficial bacteria in the gut, but will also provide the scientific basis for the development of innovative biotechnology-based products tailored to prevent specific diseases and promote overall human gastrointestinal health.
C Dunne
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Inflammatory bowel diseases     Volume:  7     ISSN:  1078-0998     ISO Abbreviation:  Inflamm. Bowel Dis.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-31     Completed Date:  2001-10-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9508162     Medline TA:  Inflamm Bowel Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  136-45     Citation Subset:  IM    
Department of Microbiology and National Food Biotechnology Centre, National University of Ireland, Cork.
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MeSH Terms
Bacterial Physiological Phenomena*
Bifidobacterium / physiology
Colonic Diseases, Functional / microbiology,  therapy*
Crohn Disease / microbiology,  therapy
Digestive System / microbiology*,  physiopathology
Inflammatory Bowel Diseases / microbiology,  therapy*
Probiotics / therapeutic use*
Species Specificity

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