Document Detail

Adamantinoid basal cell carcinoma. An ultrastructural study.
MedLine Citation:
PMID:  2039349     Owner:  NLM     Status:  MEDLINE    
We describe an adamantinoid basal cell carcinoma that has developed in the mucocutaneous border of the upper lip. An ultrastructural study disclosed three types of cells that were morphologically distinct in the tumor nest. Cells of the first type were basically the same as those of ordinary basal cell carcinoma. Cells of the second type showed varying degrees of cytoplasmic content loss in a worm-eaten pattern and seemed to consist of degenerating cells. Cells of the third type possessed a well-developed rough endoplasmic reticulum filled with medium electron-dense fine substance, which was also seen in the extracellular space. In relationship with the histochemical findings, and based on the histogenesis of adamantinoid basal cell carcinoma, we propose that subpopulations of tumor cells undergo spontaneous degeneration and that the spaces of such disappearing cells are refilled with products containing glycosaminoglycans secreted by another subpopulation of the tumor cells.
M Nishimura; Y Hori
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  115     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-06-28     Completed Date:  1991-06-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  624-6     Citation Subset:  AIM; IM    
Department of Dermatology, Kyushu University, Beppu, Japan.
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MeSH Terms
Carcinoma, Basal Cell / pathology*
Cytoplasm / pathology
Endoplasmic Reticulum / pathology
Epidermis / pathology
Lip Neoplasms / pathology*
Microscopy, Electron
Middle Aged
Mitochondria / pathology
Mucous Membrane / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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