| Adalimumab-associated pulmonary cryptococcosis. | |
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MedLine Citation:
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PMID: 21881327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This is the first report of adalimumab-associated pulmonary cryptococcosis. A 56-year-old female with rheumatoid arthritis without a history of pulmonary disease was simultaneously administered adalimumab (40 mg/2 wks), methotrexate (4 mg/wk), and isoniazid (200 mg/day). Five months later, chest radiography revealed a small spiculated pulmonary nodule, and the laboratory test results, including levels of tumor markers and plasma β-D-glucan, were within normal ranges. Since the lesion continued to grow, even after discontinuing adalimumab, it was surgically resected. Grocott staining of the tissue sample revealed black-brown fungi, identified as Cryptococcus neoformans in culture. The patient now remains well, without adalimumab therapy. |
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Authors:
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Takashi Iwata; Teruaki Nagano; Masuhiro Tomita; Yasuo Suehiro; Shin-Ichi Nakatsuka; Hayato Kimura; Masayuki Sakaki |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia Volume: 17 ISSN: 2186-1005 ISO Abbreviation: Ann Thorac Cardiovasc Surg Publication Date: 2011 |
Date Detail:
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Created Date: 2011-09-01 Completed Date: 2012-01-11 Revised Date: 2013-05-27 |
Medline Journal Info:
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Nlm Unique ID: 9703158 Medline TA: Ann Thorac Cardiovasc Surg Country: Japan |
Other Details:
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Languages: eng Pagination: 390-3 Citation Subset: IM |
Affiliation:
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Department of Thoracic Surgery, Osaka City University Graduate School of Medicine, Osaka, Osaka, Japan. taiwata@kanrou.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Infective Agents
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administration & dosage Antibodies, Monoclonal, Humanized / administration & dosage, adverse effects* Antirheumatic Agents / administration & dosage, adverse effects* Arthritis, Rheumatoid / drug therapy* Cryptococcosis / chemically induced*, diagnosis, microbiology, surgery Cryptococcus neoformans / isolation & purification* Drug Therapy, Combination Female Humans Isoniazid / administration & dosage Lung Diseases / chemically induced*, diagnosis, microbiology, surgery Methotrexate / administration & dosage Middle Aged Thoracic Surgery, Video-Assisted Tomography, X-Ray Computed Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 0/Antibodies, Monoclonal, Humanized; 0/Antirheumatic Agents; 54-85-3/Isoniazid; 59-05-2/Methotrexate; FYS6T7F842/adalimumab |
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