Document Detail

Adalimumab-associated pulmonary cryptococcosis.
MedLine Citation:
PMID:  21881327     Owner:  NLM     Status:  MEDLINE    
This is the first report of adalimumab-associated pulmonary cryptococcosis. A 56-year-old female with rheumatoid arthritis without a history of pulmonary disease was simultaneously administered adalimumab (40 mg/2 wks), methotrexate (4 mg/wk), and isoniazid (200 mg/day). Five months later, chest radiography revealed a small spiculated pulmonary nodule, and the laboratory test results, including levels of tumor markers and plasma β-D-glucan, were within normal ranges. Since the lesion continued to grow, even after discontinuing adalimumab, it was surgically resected. Grocott staining of the tissue sample revealed black-brown fungi, identified as Cryptococcus neoformans in culture. The patient now remains well, without adalimumab therapy.
Takashi Iwata; Teruaki Nagano; Masuhiro Tomita; Yasuo Suehiro; Shin-Ichi Nakatsuka; Hayato Kimura; Masayuki Sakaki
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia     Volume:  17     ISSN:  2186-1005     ISO Abbreviation:  Ann Thorac Cardiovasc Surg     Publication Date:  2011  
Date Detail:
Created Date:  2011-09-01     Completed Date:  2012-01-11     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  9703158     Medline TA:  Ann Thorac Cardiovasc Surg     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  390-3     Citation Subset:  IM    
Department of Thoracic Surgery, Osaka City University Graduate School of Medicine, Osaka, Osaka, Japan.
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MeSH Terms
Anti-Infective Agents / administration & dosage
Antibodies, Monoclonal, Humanized / administration & dosage,  adverse effects*
Antirheumatic Agents / administration & dosage,  adverse effects*
Arthritis, Rheumatoid / drug therapy*
Cryptococcosis / chemically induced*,  diagnosis,  microbiology,  surgery
Cryptococcus neoformans / isolation & purification*
Drug Therapy, Combination
Isoniazid / administration & dosage
Lung Diseases / chemically induced*,  diagnosis,  microbiology,  surgery
Methotrexate / administration & dosage
Middle Aged
Thoracic Surgery, Video-Assisted
Tomography, X-Ray Computed
Treatment Outcome
Reg. No./Substance:
0/Anti-Infective Agents; 0/Antibodies, Monoclonal, Humanized; 0/Antirheumatic Agents; 54-85-3/Isoniazid; 59-05-2/Methotrexate; FYS6T7F842/adalimumab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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