| Adalimumab-associated Pulmonary Cryptococcosis. | |
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MedLine Citation:
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PMID: 21881327 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This is the first report of adalimumab-associated pulmonary cryptococcosis. A 56-year-old female with rheumatoid arthritis without a history of pulmonary disease was simultaneously administered adalimumab (40 mg/2 wks), methotrexate (4 mg/wk), and isoniazid (200 mg/day). Five months later, chest radiography revealed a small spiculated pulmonary nodule, and the laboratory test results, including levels of tumor markers and plasma β-D-glucan, were within normal ranges. Since the lesion continued to grow, even after discontinuing adalimumab, it was surgically resected. Grocott staining of the tissue sample revealed black-brown fungi, identified as Cryptococcus neoformans in culture. The patient now remains well, without adalimumab therapy. |
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Authors:
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Takashi Iwata; Teruaki Nagano; Masuhiro Tomita; Yasuo Suehiro; Shin-Ichi Nakatsuka; Hayato Kimura; Masayuki Sakaki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia Volume: 17 ISSN: 1341-1098 ISO Abbreviation: Ann Thorac Cardiovasc Surg Publication Date: 2011 |
Date Detail:
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Created Date: 2011-09-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9703158 Medline TA: Ann Thorac Cardiovasc Surg Country: Japan |
Other Details:
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Languages: eng Pagination: 390-3 Citation Subset: IM |
Affiliation:
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Department of Thoracic Surgery, Osaka City University Graduate School of Medicine, Osaka, Osaka, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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