Document Detail


Acylcarnitine profiles of preterm infants over the first four weeks of life.
MedLine Citation:
PMID:  12409519     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Measurement of free carnitine and acylcarnitines allows the detection of several inborn errors of metabolism in neonatal screening. Because available data for premature infants is limited, we studied longitudinal changes in acylcarnitine profiles of full-term and preterm neonates over the first 4 weeks of life. One hundred twenty infants were divided into four groups of 30: A, gestational age 22 to 27 wk; B, 28 to 31 wk; C, 32 to 36 wk; and D, 37 to 41 wk. Blood samples spotted on a Guthrie card were taken on days 5 and 28. Additional specimens (groups A and B only) were collected on days 1, 3, 7, and 14. Carnitine and its acyl esters were detected by looking for the precursor ions of m/z = 85 using a PE Sciex API 365 electrospray ionization tandem mass spectrometer. Concentrations of free carnitine and most acylcarnitines were significantly higher in group A compared with group D postnatally. Groups B and C displayed intermediate values. Carnitine levels in infants from group A and B decreased steadily from day 1 to day 7, and recovered up to day 14 in group B only. On day 28 carnitine concentrations had further decreased in group A, while reaching postnatal levels again in group B. Postnatal carnitine levels are higher in very immature preterm infants compared with full-term infants, but become lower on day 28. However, the commonly used metabolite ratios should still allow the detection of inborn errors of metabolism.
Authors:
Jochen Meyburg; Andreas Schulze; Dirk Kohlmueller; Johannes Pöschl; Otwin Linderkamp; Georg F Hoffmann; Ertan Mayatepek
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  52     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-10-31     Completed Date:  2003-03-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  720-3     Citation Subset:  IM    
Affiliation:
Department of Neonatology, Division of Metabolic and Endocrine Diseases, University Children's Hospital, Im Neuenheimer Feld 150, 69120 Heidelberg, Germany. jochen_meyburg@med.uni-heidelberg.de
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MeSH Terms
Descriptor/Qualifier:
Carnitine / analogs & derivatives*,  blood*
Gestational Age
Humans
Infant, Newborn
Infant, Premature / blood*
Metabolism, Inborn Errors / blood,  diagnosis
Neonatal Screening
Spectrometry, Mass, Electrospray Ionization
Time Factors
Chemical
Reg. No./Substance:
0/acylcarnitine; 541-15-1/Carnitine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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