Document Detail


(Acylaryloxy)acetic acid diuretics. 4. Indeno[5,4-b]furan-2-carboxylic acids.
MedLine Citation:
PMID:  7277396     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Investigation of the chemistry of the potent new uricosuric diuretic indacrinone (MK-196) led to a class of novel annulated derivatives, indeno[5,4-b]furan-2-carboxylic acids. The structural requirements for optimal diuretic and uricosuric activity of the tricyclic analogues differed from those of their (indanyloxy)acetic acids counterparts. Most notably, the tricyclic analogues were two to four times more natriuretic than the corresponding (indanyloxy)acetic acids when administered orally to rats, and in chimpanzees, uricosuria was observed only in those indenofurans having a nuclear aryl substituent.
Authors:
O W Woltersdorf; S J deSolms; E J Cragoe
Related Documents :
19336926 - Development of des-fatty acyl-polymyxin b decapeptide analogs with pseudomonas aerugino...
15454216 - Design and synthesis of 1-(4-benzoylphenyl)imidazole derivatives as new potent 20-hete ...
21599946 - The impact of fads genetic variants on ω6 polyunsaturated fatty acid metabolism in afri...
2002456 - Synthesis and biological activity of 5-alkyl-1,7,8-trisubstituted-6-fluoroquinoline-3-c...
14633676 - In vivo monitoring of capecitabine metabolism in human liver by 19fluorine magnetic res...
4202956 - Quantitative chemical composition of peptidoglycan of listeria monocytogenes.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  24     ISSN:  0022-2623     ISO Abbreviation:  J. Med. Chem.     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-11-18     Completed Date:  1981-11-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  874-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Chemical Phenomena
Chemistry
Diuretics / chemical synthesis*
Indans / chemical synthesis*,  pharmacology
Indenes / chemical synthesis*
Pan troglodytes
Rats
Species Specificity
Structure-Activity Relationship
Uricosuric Agents / chemical synthesis*
Chemical
Reg. No./Substance:
0/Diuretics; 0/Indans; 0/Indenes; 0/Uricosuric Agents; 56049-88-8/indanone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  (Acylaryloxy)acetic acid diuretics. 3. 2,3-Dihydro-5-acyl-2-benzofurancarboxylic acids, a new class ...
Next Document:  Synthesis and antiallergy activity of 4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidines.