Document Detail


Acyl group distributions in tissue lipids of rats fed evening primrose oil (gamma -linolenic plus linoleic acid) or soybean oil (alpha-linolenic plus linoleic acid).
MedLine Citation:
PMID:  6318009     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three groups of rats were fed diets with either 10 weight percent (wt%) of evening primrose oil, safflower oil or soybean oil for 11 weeks. Diets contained 7.1 wt% linoleic acid + 0.8 wt% gamma-linolenic acid, 7.6 wt% linoleic acid, or 5.3 wt% linoleic acid + 0.7 wt% alpha-linolenic acid, respectively. In liver mitochondria as well as in heart, dietary gamma-linolenic acid did not affect the fatty acid profiles of phosphatidylcholines (PC), phosphatidylethanolamines (PE) or cardiolipins (CL), whereas dietary alpha-linolenic acid caused an increased formation of (n-3) polyunsaturated fatty acids (PUFA). The liver delta 6- and delta 5-desaturase activities determined in vitro were not affected by the dietary fats. In brain PE, which are rich in C22- and C20-(n-3) PUFA, as well as in testes PC and PE, which are rich in (n-6) PUFA, no effects were found from a partial replacement of dietary linoleic acid with gamma-linolenic acid or alpha-linolenic acid. In kidney PC, PE, phosphatidylinositol (PI) and CL, 20:3(n-6) was moderately elevated to ca. 1% following intake of gamma-linolenic acid, whereas partial replacement of linoleic acid with alpha-linolenic acid was followed by increased deposition of 22:6(n-3) in PC and PE of testes and kidney. Thus, no general effect of evening primrose oil on the content of (n-6) PUFA in rat tissue phospholipids was observed, whereas a significant incorporation of gamma-linolenic acid into liver and adipose tissue triglycerides was found.
Authors:
C E Høy; G Hølmer; N Kaur; I Byrjalsen; D Kirstein
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lipids     Volume:  18     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1984-02-14     Completed Date:  1984-02-14     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  760-71     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Dietary Fats / pharmacology*
Fatty Acid Desaturases / metabolism
Linoleic Acid
Linoleic Acids / pharmacology*
Linolenic Acids / pharmacology*
Linoleoyl-CoA Desaturase
Lipids / analysis*
Male
Microsomes, Liver / enzymology
Rats
Rats, Inbred Strains
Tissue Distribution
alpha-Linolenic Acid
gamma-Linolenic Acid
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Linoleic Acids; 0/Linolenic Acids; 0/Lipids; 2197-37-7/Linoleic Acid; 463-40-1/alpha-Linolenic Acid; 506-26-3/gamma-Linolenic Acid; EC 1.14.19.-/Fatty Acid Desaturases; EC 1.14.19.3/Linoleoyl-CoA Desaturase; EC 1.14.99.-/delta-5 fatty acid desaturase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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