Document Detail


Acyl-CoA binding proteins; structural and functional conservation over 2000 MYA.
MedLine Citation:
PMID:  17013545     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Besides serving as essential substrates for beta-oxidation and synthesis of triacylglycerols and more complex lipids like sphingolipids and sterol esters, long-chain fatty acyl-CoA esters are increasingly being recognized as important regulators of enzyme activities and gene transcription. Acyl-CoA binding protein, ACBP, has been proposed to play a pivotal role in the intracellular trafficking and utilization of long-chain fatty acyl-CoA esters. Depletion of acyl-CoA binding protein in yeast results in aberrant organelle morphology incl. fragmented vacuoles, multi-layered plasma membranes and accumulation of vesicles of variable sizes. In contrast to synthesis and turn-over of glycerolipids, the levels of very-long-chain fatty acids, long-chain bases and ceramide are severely affected by Acb1p depletion, suggesting that Acb1p, rather than playing a general role, serves specific roles in cellular lipid metabolism.
Authors:
Nils J Faergeman; Majken Wadum; Søren Feddersen; Mark Burton; Birthe B Kragelund; Jens Knudsen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  299     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-11     Completed Date:  2007-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  55-65     Citation Subset:  IM    
Affiliation:
Department of Biochemistry and Molecular Biology, University of Southern Denmark, Campusvej 55, DK-5230, Odense M, Denmark. nils.f@bmb.sdu.dk
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MeSH Terms
Descriptor/Qualifier:
Animals
Diazepam Binding Inhibitor / chemistry*,  classification,  metabolism*
Humans
Phylogeny
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Diazepam Binding Inhibitor

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