Document Detail

Acyclovir plus steroid vs steroid alone in the treatment of Bell's palsy.
MedLine Citation:
PMID:  18439948     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The pathogenetic mechanism of Bell's palsy is thought to involve herpes simplex virus reactivation within the geniculate ganglion, followed by inflammation and entrapment of the nerve at the meatal foramen. We therefore compared the therapeutic effect of acyclovir plus steroid vs steroid alone, in combination with physical therapy, in patients with Bell's palsy. MATERIALS AND METHODS: In a double-blind, randomized, prospective trial, 91 patients were randomized to treatment with acyclovir and prednisone (44 patients) or prednisone alone (47 patients). All patients underwent physical therapy. The follow-up period was greater than 6 months or encompassed the period of complete recovery from paralysis. House-Brackmann grade was evaluated 2 and 6 months after onset, with complete and satisfactory recovery defined as House-Brackmann grades I and II, respectively. RESULTS: The overall recovery rate of patients treated with steroid and acyclovir (93.1%) was greater than that of patients treated with steroid alone (85.1%), but the difference was not statistically significant. CONCLUSION: The benefit of acyclovir in Bell's palsy has not been definitively established.
Seung Geun Yeo; Young Chan Lee; Dong Choon Park; Chang Il Cha
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2008-03-17
Journal Detail:
Title:  American journal of otolaryngology     Volume:  29     ISSN:  1532-818X     ISO Abbreviation:  Am J Otolaryngol     Publication Date:    2008 May-Jun
Date Detail:
Created Date:  2008-04-28     Completed Date:  2008-12-18     Revised Date:  2009-11-02    
Medline Journal Info:
Nlm Unique ID:  8000029     Medline TA:  Am J Otolaryngol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  163-6     Citation Subset:  IM    
Department of Otolaryngology, College of Medicine, Kyung Hee University, Seoul, South Korea.
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MeSH Terms
Acyclovir / therapeutic use*
Administration, Oral
Antiviral Agents / administration & dosage,  therapeutic use*
Bell Palsy / drug therapy*,  physiopathology
Double-Blind Method
Drug Therapy, Combination
Follow-Up Studies
Glucocorticoids / therapeutic use*
Patient Satisfaction
Prednisone / administration & dosage,  therapeutic use*
Prospective Studies
Recovery of Function
Treatment Outcome
Reg. No./Substance:
0/Antiviral Agents; 0/Glucocorticoids; 53-03-2/Prednisone; 59277-89-3/Acyclovir
Comment In:
Am J Otolaryngol. 2009 Nov-Dec;30(6):435; author reply 435-6   [PMID:  19880037 ]

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