Document Detail


Acyclovir-induced neutropenia in an infant with herpes simplex encephalitis: case report.
MedLine Citation:
PMID:  7548511     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A newborn infant whose condition was diagnosed as herpes simplex encephalitis and who had subsequent recurrences of skin disease had repeated episodes of neutropenia while receiving therapy with intravenous (30 mg/[kg.d]) or oral (30 mg/]kg.d]) acyclovir. The neutropenia did not recur when the dosage of oral acyclovir was reduced to 10 mg/(kg.d). This case represents the first well-documented report of acyclovir-induced neutropenia.
Authors:
H M Feder; R K Goyal; P J Krause
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  20     ISSN:  1058-4838     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-11-07     Completed Date:  1995-11-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1557-9     Citation Subset:  IM    
Affiliation:
Department of Pediatrics and Family Medicine, University of Connecticut Health Center, Farmington 06030-3960, USA.
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MeSH Terms
Descriptor/Qualifier:
Acyclovir / adverse effects*,  therapeutic use
Encephalitis, Viral / cerebrospinal fluid,  complications,  drug therapy*,  virology
Female
Follow-Up Studies
Herpesvirus 2, Human* / drug effects
Humans
Infant, Newborn
Magnetic Resonance Imaging
Neutropenia / cerebrospinal fluid,  chemically induced*,  complications
Chemical
Reg. No./Substance:
59277-89-3/Acyclovir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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