| Acyclovir in the treatment of idiopathic sudden sensorineural hearing loss. | |
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MedLine Citation:
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PMID: 12707659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Idiopathic sudden sensorineural hearing loss (ISSNHL) is a vexing problem that continues to pose a diagnostic and therapeutic enigma for the otologist. The aim of the study, adopting the viral theory, was to discover whether patients with ISSNHL would benefit from early treatment with acyclovir and hydrocortisone compared with patients treated by hydrocortisone alone. METHODS: Sixty patients with ISSNHL were treated in a prospective controlled randomized manner. Patients were seen within 7 days of onset and were divided randomly into 2 groups. The study group patients were treated with acyclovir and hydrocortisone, whereas those in the control group were treated with hydrocortisone alone. RESULTS: We compared the 2 groups before and after treatment regarding SRT, mean hearing level at each frequency, speech reception threshold improvement, gender, age, tinnitus, and balance complaints. The overall improvement was 78%. CONCLUSION: We conclude that there probably is no benefit from the addition of acyclovir in the treatment of ISSNHL. |
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Authors:
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Nechama Uri; Ilana Doweck; Raanan Cohen-Kerem; Elhanan Greenberg |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery Volume: 128 ISSN: 0194-5998 ISO Abbreviation: Otolaryngol Head Neck Surg Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-04-22 Completed Date: 2003-06-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8508176 Medline TA: Otolaryngol Head Neck Surg Country: United States |
Other Details:
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Languages: eng Pagination: 544-9 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology-Head and Neck Surgery, Carmel Medical Center, Haifa, Israel. druri@netvision.net.il |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acyclovir
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therapeutic use* Adolescent Adult Antiviral Agents / therapeutic use* Female Hearing Loss, Sensorineural / drug therapy* Hearing Loss, Sudden / drug therapy* Humans Male Middle Aged Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 59277-89-3/Acyclovir |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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