| Acyclovir in Pregnancy Registry. An observational epidemiologic approach. | |
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MedLine Citation:
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PMID: 3407674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Observational epidemiologic methods are being used to evaluate the safety of acyclovir in pregnancy. An essential component of this research is the establishment of a baseline expectation of pregnancy outcomes among women with herpes not receiving acyclovir. Continuing studies will be described in this report. To supplement these structured studies, an international case registration study was established. Through the Acyclovir in Pregnancy Registry, all cases of reported prenatal exposures to acyclovir are tracked to ascertain maternal exposure, risk factor, and pregnancy outcome information. The reports originate in all countries where oral acyclovir is marketed; data consolidation and analysis are coordinated at Burroughs Wellcome Co. with the assistance of a government/industry advisory panel. This presentation summarizes provisional data from the prospective reports, including trimester of exposure and reported outcomes of pregnancy. The total number of monitored pregnancies remains too small to support conclusions about the safety of acyclovir during pregnancy at this point. The potential for the registry and other epidemiologic studies to address the safety-in-pregnancy question will be discussed. |
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Authors:
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E B Andrews; H H Tilson; B A Hurn; J F Cordero |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of medicine Volume: 85 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1988 Aug |
Date Detail:
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Created Date: 1988-09-22 Completed Date: 1988-09-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 123-8 Citation Subset: AIM; IM |
Affiliation:
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Epidemiology, Information and Surveillance Division, Burroughs Wellcome Co., Burroughs Research Triangle Park, North Carolina 27709. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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prevention & control* Acyclovir / adverse effects*, therapeutic use Evaluation Studies as Topic* Female Great Britain Herpes Simplex / drug therapy* Humans Pregnancy Pregnancy Complications, Infectious / drug therapy* Pregnancy Outcome* Product Surveillance, Postmarketing* Prospective Studies Registries United States |
| Chemical | |
Reg. No./Substance:
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59277-89-3/Acyclovir |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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