Document Detail

Acute zonal occult outer retinopathy: towards a set of diagnostic criteria.
MedLine Citation:
PMID:  15615750     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Individuals with acute zonal occult outer retinopathy (AZOOR) present with initially progressive scotomata and photopsia. Characteristically, the extent of the visual field defect is unexplained by fundal examination, but there is marked retinal dysfunction evident electrophysiologically. It is the authors' experience that a group of patients exhibit characteristic clinical and electrophysiological abnormalities, which serve as criteria for a working diagnosis.
METHODS: A retrospective observational case series of 28 patients were identified with the clinical diagnosis of AZOOR who shared similar abnormal electrophysiology. Details of the history and ophthalmic findings were obtained from the case notes.
RESULTS: Electrophysiology demonstrated a consistent pattern of dysfunction both at the photoreceptor/retinal pigment epithelial complex but also at inner retinal levels, essentially comprising a delayed 30 Hz flicker ERG and a reduction in the EOG light rise.
CONCLUSION: This study determines diagnostic criteria applicable to a group of patients with AZOOR, typically those with classic symptomatology. Electrophysiological testing can help avoid lengthy, costly, and potentially invasive investigations, and the unnecessary use of immunosuppressive therapy.
P J Francis; A Marinescu; F W Fitzke; A C Bird; G E Holder
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  89     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-23     Completed Date:  2005-01-18     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  70-3     Citation Subset:  IM    
Department of Electrophysiology, Moorfields Eye Hospital, 162 City Road, London EC1V 2PD, UK.
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MeSH Terms
Acute Disease
Electrooculography / methods
Electroretinography / methods
Fundus Oculi
Middle Aged
Retinal Diseases / diagnosis*,  pathology,  physiopathology
Retrospective Studies
Scotoma / physiopathology
Vision Disorders / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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