Document Detail

Acute volume expansion as a physiological stimulus for the release of atrial natriuretic peptides in the rat.
MedLine Citation:
PMID:  2937986     Owner:  NLM     Status:  MEDLINE    
The concentration of immunoreactive atrial natriuretic peptide(s) (ANP) was measured in normovolemic conscious rats and 15 min after 10% and 20% blood volume expansion. A 20% blood volume expansion caused a 2-fold increase in plasma ANP. While plasma ANP increased linearly, atrial levels of ANP remained unaltered. The increase in plasma ANP parallelled increases of central blood volume and central venous pressure. It is concluded that acute blood volume expansion is a major physiological stimulus for the release of atrial natriuretic peptides into the circulation.
A Pettersson; J Hedner; S E Ricksten; A C Towle; T Hedner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  38     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-04-28     Completed Date:  1986-04-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1127-33     Citation Subset:  IM    
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MeSH Terms
Atrial Natriuretic Factor / blood*
Blood Volume*
Central Venous Pressure
Heart Rate
Rats, Inbred WKY
Stroke Volume
Vascular Resistance
Reg. No./Substance:
85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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