Document Detail


Acute versus chronic myocardial ischemia: a differential biological profile study.
MedLine Citation:
PMID:  19127089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the possible differences in lipid, thrombogenic and inflammatory marker concentrations and the presence of chronic and acute coronary artery disease (stable and unstable angina, respectively), comparing them with a group of control patients with normal coronary arteries. MATERIAL AND METHODS: This prospective cohort study included 125 patients with unstable angina, 189 with stable angina and a control group of 83 patients with normal coronary arteries. Marker concentrations were measured in all 3 groups. Logistic regression analysis was performed to determine whether such factors could predict unstable or stable angina. RESULTS: Lipid parameter concentrations were similar in the 2 coronary disease groups and significantly lower than in controls. Haemostatic and inflammatory marker concentrations were higher in patients with coronary disease, but were statistically significant only when comparing unstable angina patients with normal controls. Unstable angina patients had significantly higher levels of lipoprotein (a) [Lp(a)], fibrinogen, C-reactive protein (CRP) and leucocytes. Multiple logistic regression analysis showed that CRP (OR 2.635, 95% CI 1.417-4.898), smoking (OR 3.416, 95% CI 1.773-6.584), leucocytes (OR 2.034, 95% CI 1.079-3.836) and Lp(a) (OR 2.269, 95% CI 1.188-4.334) were independent risk factors of unstable versus stable angina. CONCLUSIONS: Patients with unstable angina present a more atherogenic profile than patients with stable angina. Together with smoking, elevated Lp(a), CRP and leucocyte concentrations proved to be associated with the presence of unstable angina.
Authors:
José Domingo Sagastagoitia; Yolanda Sáez; Marta Vacas; Idoia Narváez; Jesús Pablo Sáez de Lafuente; Enrique Molinero; Antonio Escobar; Manuel Lafita; José Antonio Iriarte
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-01-05
Journal Detail:
Title:  Pathophysiology of haemostasis and thrombosis     Volume:  36     ISSN:  1424-8840     ISO Abbreviation:  Pathophysiol. Haemost. Thromb.     Publication Date:  2008  
Date Detail:
Created Date:  2009-01-07     Completed Date:  2009-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101142710     Medline TA:  Pathophysiol Haemost Thromb     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  91-7     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Affiliation:
Servicio Cardiología, Hospital de Basurto, Departamento de Medicina, Universidad del País Vasco UPV/EHU, Bilbao, Spain.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Aged
Angina, Unstable / blood,  etiology*,  pathology
Biological Markers / analysis
Case-Control Studies
Chronic Disease
Female
Humans
Inflammation
Leukocyte Count
Lipids / blood*
Lipoprotein(a) / blood
Male
Microvascular Angina / blood,  etiology*,  pathology
Middle Aged
Myocardial Ischemia / blood,  etiology*,  pathology
Prospective Studies
Risk Factors
Smoking
Thrombosis
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Lipids; 0/Lipoprotein(a)

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