Document Detail


Acute ventricular and aortic thrombosis post chemotherapy.
MedLine Citation:
PMID:  17551165     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present a rare case of spontaneous arterial thrombosis in a 42-year-old male with an acute history of bilateral lower limb pain and weakness. The previous day he had received the first cycle of cisplatin-based chemotherapy for oesophageal adenocarcinoma (T2/3N0/M0). Computed tomography (CT) and angiography showed extensive abdominal aortic thrombus in a native non-aneurysmal or grossly atheromatous aorta with separate thrombus in the left ventricle. We suggest that poor left ventricular function, a hypercoaguable state secondary to malignancy and cisplatin based chemotherapy may have induced severe arterial and intra-cardiac thrombosis.
Authors:
J F Morlese; T Jeswani; I Beal; P Wylie; J Bell
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The British journal of radiology     Volume:  80     ISSN:  1748-880X     ISO Abbreviation:  Br J Radiol     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-06-06     Completed Date:  2007-07-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373125     Medline TA:  Br J Radiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  e75-7     Citation Subset:  AIM; IM    
Affiliation:
Royal Free Hospital, Pond Street, London, UK. james.bell@royalfree.nhs.uk
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adenocarcinoma / drug therapy
Adult
Antineoplastic Combined Chemotherapy Protocols / adverse effects*
Aortic Diseases / chemically induced*,  radiography
Esophageal Neoplasms / drug therapy
Fatal Outcome
Heart Diseases / chemically induced*,  radiography
Heart Ventricles
Humans
Male
Thrombosis / chemically induced*,  radiography
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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