Document Detail

Acute ventilatory restriction in children after weaning off inhaled nitric oxide: relation to rebound pulmonary hypertension.
MedLine Citation:
PMID:  10051082     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the interaction between pulmonary hemodynamics and respiratory mechanics during acute pulmonary hypertension. PATIENTS: Ventilated and paralysed children treated with inhaled nitric oxide because of post-operative pulmonary hypertension. INTERVENTIONS: Weaning of inhaled nitric oxide. MEASUREMENTS: Air flow and airway pressure, calculation of dynamic respiratory system compliance and respiratory system resistance for each breath by multiple linear regression. RESULTS: In four patients, increases in pulmonary arterial pressure from 26.1 to 56.7 mm Hg (p<0.001) during weaning off nitric oxide were associated with decreases in tidal volume (from 9.7-->8.2 ml/kg, p<0.01) and reductions in dynamic respiratory system compliance (from 0.52-->0.34 cm H20/ml/kg, p<0.001), while respiratory system resistance was unchanged. CONCLUSIONS: Impaired ventilation during acute pulmonary hypertension is predominantly related to a reduction in respiratory system compliance.
I Schulze-Neick; H Werner; D J Penny; V Alexi-Meskishvili; P E Lange
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Intensive care medicine     Volume:  25     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-05-20     Completed Date:  1999-05-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  76-80     Citation Subset:  IM    
Abteilung Angeborene Herzfehler, Deutsches Herzzentrum Berlin, Germany.
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MeSH Terms
Administration, Inhalation
Heart Defects, Congenital / surgery*
Hypertension, Pulmonary / drug therapy*,  etiology,  therapy
Linear Models
Nitric Oxide / administration & dosage,  therapeutic use*
Positive-Pressure Respiration*
Postoperative Complications
Respiratory Mechanics*
Vasodilator Agents / administration & dosage,  therapeutic use*
Ventilator Weaning*
Reg. No./Substance:
0/Vasodilator Agents; 10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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