Document Detail


Acute variations in retinal vascular oxygen content in a rabbit model of retinal venous occlusion.
MedLine Citation:
PMID:  23185567     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To study the variation in intravascular oxygen saturation (oximetry) during an acute retinal vein occlusion (RVO) using hyperspectral computed tomographic spectroscopy based oximetry measurements.
METHODS: Thirty rabbits were dilated and anesthetized for experiments. Baseline oximetry measurements were made using a custom-made hyperspectral computed tomographic imaging spectrometer coupled to a fundus camera. RVO were induced using argon green laser following an intravenous injection of Rose Bengal. RVO induction was confirmed by fluorescein angiography. Retinal oximetry measurements were repeated in arterial and venous branches one hour after RVO induction and up to 4 weeks afterwards. Comparison of retinal oximetry before and after vein occlusion was made using the Student T-test.
RESULTS: One hour after RVO induction, we observed statistically significant reductions in the intravascular oxygen saturation in temporal retinal arteries (85.1 ± 6.1% vs. 80.6 ± 6.6%; p<0.0001) and veins (71.4 ± 5.5% vs. 64.0 ± 4.7%; p<0.0001). This decrease was reversible in animals that spontaneously recannulated the vein occlusion. There were no statistically significant differences in oxygen saturation in the nasal control arteries and veins before and after temporal vein RVO induction.
CONCLUSIONS: We demonstrate, for the first time, acute changes in the intravascular oxygen content of retinal vessels 1 hour after RVO. These changes are reversible upon spontaneous recannulation of retinal vessels. This study demonstrates that hyperspectral computer tomographic spectroscopy based oximetry can detect physiological variations in intravascular retinal oxygen saturation. The study also provides the first qualitative and quantitative evidence of the variation in retinal vascular oxygen content directly attributable to an acute retinal vein occlusion.
Authors:
Gilberto Raul Lopez Jaime; Amir H Kashani; Saloomeh Saati; Gabriel Martin; Gerald Chader; Mark S Humayun
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-20
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-27     Completed Date:  2013-05-13     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e50179     Citation Subset:  IM    
Affiliation:
Doheny Eye Institute, University of Southern California, Los Angeles California, United States of America.
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Fluorescein
Fluorescein Angiography
Fluorescent Dyes
Oximetry / methods
Oxygen / metabolism*
Rabbits
Retina / metabolism*,  pathology
Retinal Artery / metabolism
Retinal Vein / metabolism*,  pathology
Retinal Vein Occlusion / metabolism*,  pathology
Rose Bengal
Chemical
Reg. No./Substance:
0/Fluorescent Dyes; 11121-48-5/Rose Bengal; 2321-07-5/Fluorescein; 7782-44-7/Oxygen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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