Document Detail


Acute treatment of hyperammonemia by continuous renal replacement therapy in a newborn patient with ornithine transcarbamylase deficiency.
MedLine Citation:
PMID:  22232626     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Ornithine transcarbamylase (OTC) deficiency is well known as the most common inherited disorder of the urea cycle, and 1 of the most common causes of hyperammonemia in newborns. We experienced a case of a 3-day-old boy with OTC deficiency who appeared healthy in the first 2 days of life but developed lethargy and seizure soon afterwards. His serum ammonia level was measured as >1700 µg/dL (range, 0 to 45 µg/dL). Continuous renal replacement therapy (CRRT) in the mode of continuous venovenous hemodiafiltration was immediately applied to correct the raised ammonia level. No seizure occurred after the elevated ammonia level was reduced. Therefore, CRRT should be included as 1 of the treatment modalities for newborns with inborn errors of metabolism, especially hyperammonemia. Here, we report 1 case of successful treatment of hyperammonemia by CRRT in a neonate with OTC deficiency.
Authors:
Hyo Jeong Kim; Se Jin Park; Kook In Park; Jin Sung Lee; Ho Sun Eun; Ji Hong Kim; Jae Il Shin
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Publication Detail:
Type:  Journal Article     Date:  2011-10-31
Journal Detail:
Title:  Korean journal of pediatrics     Volume:  54     ISSN:  2092-7258     ISO Abbreviation:  Korean J Pediatr     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2012-01-10     Completed Date:  2012-10-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101215374     Medline TA:  Korean J Pediatr     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  425-8     Citation Subset:  -    
Affiliation:
The Institute of Kidney Disease, Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
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