Document Detail


Acute transformation in nonleukemic chronic myeloproliferative disorders: actuarial probability and main characteristics in a series of 218 patients.
MedLine Citation:
PMID:  2042444     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a series of 218 subjects diagnosed as having nonleukemic chronic myeloproliferative disorders in a single institution within a 18-year period, 13 instances of acute transformation were registered. They corresponded to 8 out of 70 patients with idiopathic myelofibrosis (IM), 4 out of 91 with polycythemia vera (PV), and 1 out of 57 with essential thrombocythemia (ET). The actuarial probability of developing such a complication at 100 months from diagnosis reached 20.6% in IM, 8.7% in PV, and 4% in ET. Only 1 IM patient whose condition developed into acute leukemia had received prior cytolytic therapy, whereas, in contrast, all PV and ET patients showing this pattern had previously been treated with either 32P or alkylating agents. On the other hand, acute transformation in IM generally had an insidious presentation, contrasting with its abrupt onset in most PV and ET patients. Most acute leukemias (12 out of 13) exhibited a myeloid phenotype. The patients' median survival from diagnosis of the acute transformation was only 3 months, the development of this complication significantly shortening the patients' overall survival.
Authors:
F Cervantes; D Tassies; C Salgado; M Rovira; A Pereira; C Rozman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta haematologica     Volume:  85     ISSN:  0001-5792     ISO Abbreviation:  Acta Haematol.     Publication Date:  1991  
Date Detail:
Created Date:  1991-07-10     Completed Date:  1991-07-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  124-7     Citation Subset:  IM    
Affiliation:
Postgraduate School of Hematology Farreras Valentí, Hospital Clínico, University of Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Actuarial Analysis*
Acute Disease
Chronic Disease
Combined Modality Therapy
Humans
Myeloproliferative Disorders / complications*,  epidemiology,  mortality
Polycythemia Vera / epidemiology,  etiology,  mortality,  therapy
Primary Myelofibrosis / epidemiology,  etiology,  mortality,  therapy
Probability
Spain / epidemiology
Survival Analysis
Thrombocythemia, Essential / epidemiology,  etiology,  mortality,  therapy

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