| Acute toxicity of widely used pharmaceuticals in aquatic species: Gambusia holbrooki, Artemia parthenogenetica and Tetraselmis chuii. | |
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MedLine Citation:
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PMID: 15922808 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pharmaceuticals are continuously dispersed into the environment as a result of human and veterinary use, posing relevant environmental concerns. This study evaluated the acute toxicity of three therapeutic agents (diazepam, clofibrate, and clofibric acid) and a detergent (sodium dodecyl sulfate; SDS) in three aquatic species, namely the euryhaline fish Gambusia holbrooki, the hypersaline crustacean Artemia parthenogenetica, and the marine algae Tetraselmis chuii. The ranking of 50% lethal concentrations (LC50) for the two animal species and 50% inhibitory concentration (IC50) for the algal species was, in decreasing order, clofibric acid > SDS > diazepam > clofibrate for G. holbrooki, clofibric acid > clofibrate > SDS > diazepam for A. parthenogenetica, and clofibric acid > clofibrate > SDS > diazepam for T. chuii. These differences show that the intrinsic nature of test organisms must be considered when evaluating the toxicity of these agents to aquatic ecosystems. |
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Authors:
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B Nunes; F Carvalho; L Guilhermino |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Ecotoxicology and environmental safety Volume: 61 ISSN: 0147-6513 ISO Abbreviation: Ecotoxicol. Environ. Saf. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-05-30 Completed Date: 2005-10-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7805381 Medline TA: Ecotoxicol Environ Saf Country: United States |
Other Details:
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Languages: eng Pagination: 413-9 Citation Subset: IM |
Affiliation:
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ICBAS, Instituto de Ciências Biomédicas Abel Salazar, Departamento de Estudos de Populações, Laboratório de Ecotoxicologia, Universidade do Porto, Largo Prof. Abel Salazar, 2, 4099-003 Porto, Portugal. brunonunes@cimar.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algae Animals Anticonvulsants / toxicity* Antilipemic Agents / toxicity* Artemia Clofibrate / toxicity* Clofibric Acid / toxicity* Cyprinodontiformes Detergents / toxicity* Diazepam / toxicity* Lethal Dose 50 Reference Values Sodium Dodecyl Sulfate / toxicity* Water Pollutants, Chemical / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Antilipemic Agents; 0/Detergents; 0/Water Pollutants, Chemical; 151-21-3/Sodium Dodecyl Sulfate; 439-14-5/Diazepam; 637-07-0/Clofibrate; 882-09-7/Clofibric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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