| Acute toxicity and irritation of water-based dextran-coated magnetic fluid injected in mice. | |
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MedLine Citation:
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PMID: 17806122 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Based on the elements that magnetic nanoparticles could heat in an alternating magnetic field, magnetic fluid hyperthermia occurred to inhibit tumor growth in vivo. However, biocompatibility of those fluids as well as the fluid-body interaction remains unclear. In this article, acute toxicity and irritation of the water-based dextran-coated magnetic fluid (dextran-magnetic fluid) injected into mice subcutaneous tissues were examined. Lethal dosage 50 of single treatment with the magnetic fluid was 4409.61 +/- 514.93 mg/kg. When injected with 30 mg/0.3 mL dextran-magnetic fluid, activities of glutamicoxalacetictransaminase (AST) and glutamicpyruvictransaminase (ALT) and cell number of mice blood did not change statistically. Hemangiectasia and leucocytes infiltration were seen in subcutaneous tissues and these phenomena almost disappeared 72 h later. That is to say, the dextran-magnetic fluid was tolerable, safe, and biocompatible. The work is a basic for application of the dextran-magnetic fluid in subcutaneous tumor therapy. |
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Authors:
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Zhai Yu; Wang Xiaoliang; Wang Xuman; Xie Hong; Gu Hongchen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomedical materials research. Part A Volume: 85 ISSN: 1552-4965 ISO Abbreviation: - Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-04-28 Completed Date: 2008-07-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101234237 Medline TA: J Biomed Mater Res A Country: United States |
Other Details:
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Languages: eng Pagination: 582-7 Citation Subset: IM |
Copyright Information:
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Copyright 2007 Wiley Periodicals, Inc. |
Affiliation:
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Research Institute of Micro/Nanometer Science and Technology, Shanghai Jiao Tong University, Shanghai 200030, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chemotaxis, Leukocyte Dextrans Hyperthermia, Induced / methods* Magnetics* Mice Neoplasms / therapy* Treatment Outcome Water |
| Chemical | |
Reg. No./Substance:
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7732-18-5/Water; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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