| Acute toxicity of ammonium metavanadate in mice. | |
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MedLine Citation:
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PMID: 6984469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute toxicity of ammonium metavanadate solutions in normal saline (pH 6.7) or 0.1 M Tris-HCl-NaCl buffers (pH 7.2 or pH 7.8) was studied in BALB/c mice at 20 mg V/kg. Animals receiving these solutions subcutaneously started to show severe clinical signs 10-15 min postinjection and high mortality rates (45-73%) during the first 3 d. Animals dying because of vanadium toxicity did so only within the first 3 d after injection. NH4VO3-treated animals showed a tendency to increase their liver and spleen weights as compared to those receiving control solutions. Severe necrosis in lymphoid tissues (thymus, spleen, lymph nodes, and Peyer's patch), pulmonary hemorrhage, and renal acute tubular necrosis were commonly demonstrated in vanadium-treated animals. Toxicity of NH4VO3 solution in 0.1 M Tris-HCl-NaCl buffer (pH 7.8) was greatly reduced upon acidification with HCl to pH 6.1 or following boiling for 15 min (final pH of 7.7). Acidification of the solution reduced the mortality rate to 20 from 68%; however, the clinical signs were still severe. Boiling of the solution reduced the mortality rate to zero and moderated the severity of the clinical signs. |
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Authors:
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C I Wei; M A Al Bayati; M R Culbertson; L S Rosenblatt; L D Hansen |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of toxicology and environmental health Volume: 10 ISSN: 0098-4108 ISO Abbreviation: J Toxicol Environ Health Publication Date: 1982 Oct-Nov |
Date Detail:
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Created Date: 1983-04-07 Completed Date: 1983-04-07 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7513622 Medline TA: J Toxicol Environ Health Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 673-87 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alopecia
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chemically induced Animals Blood / drug effects Hot Temperature Kidney Tubular Necrosis, Acute / chemically induced Liver / drug effects Lung / drug effects Lymphoid Tissue / pathology Male Mice Mice, Inbred BALB C Necrosis Organ Size / drug effects Spleen / drug effects Vanadium / toxicity* |
| Chemical | |
Reg. No./Substance:
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7440-62-2/Vanadium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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