| Acute tocolysis for uterine activity reduction in term labor: a review. | |
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MedLine Citation:
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PMID: 18492294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This review critically evaluates the efficacy of different tocolytics in reducing uterine pressure and contractions in term labor. The available evidence supports the use of beta-adrenergic-receptor agonists such as terbutaline or ritodrine; they appear to have an immediate and comparable profound effect on uterine activity in term labor. However, the preferred type of beta-adrenergic receptor agonist and dosage are unclear. The oxytocin receptor antagonist atosiban has a high specificity for the uterus with limited or no systemic effects and could therefore be an attractive alternative for use in term labor. The evidence on the tocolytic potency of a single bolus of atosiban for tocolysis in term labor is encouraging but limited and needs further research. Moreover, atosiban lacks United States Food and Drug Administration approval. Literature documenting efficacy and safety of nitroglycerin or magnesium sulfate in term labor is far from convincing. The theoretical basis for the use of tocolytics for nonreassuring intrapartum fetal heart rate patterns is to reduce the aggravating influence of uterine contractions. However, the clinical evidence that tocolytics in term active labor are actually beneficial in improving neonatal outcome is very limited. |
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Authors:
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Roel de Heus; Eduard J H Mulder; Jan B Derks; Gerard H A Visser |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Obstetrical & gynecological survey Volume: 63 ISSN: 0029-7828 ISO Abbreviation: Obstet Gynecol Surv Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-21 Completed Date: 2008-10-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401007 Medline TA: Obstet Gynecol Surv Country: United States |
Other Details:
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Languages: eng Pagination: 383-8; quiz 405 Citation Subset: IM |
Affiliation:
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Department of Perinatology and Gynecology, University Medical Centre Utrecht, The Netherlands. roeldeheus@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Agonists
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administration & dosage* Female Humans Labor, Obstetric / drug effects*, physiology Nitric Oxide / metabolism Nitroglycerin / administration & dosage Pregnancy Ritodrine / administration & dosage* Terbutaline / administration & dosage Tocolytic Agents / administration & dosage* Uterine Contraction / drug effects* Vasotocin / administration & dosage, analogs & derivatives |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Agonists; 0/Tocolytic Agents; 10102-43-9/Nitric Oxide; 23031-25-6/Terbutaline; 26652-09-5/Ritodrine; 55-63-0/Nitroglycerin; 9034-50-8/Vasotocin; 90779-69-4/atosiban |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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