| Acute thrombotic thrombocytopenic purpura following orthopedic surgery: a case report. | |
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MedLine Citation:
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PMID: 16525809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thrombotic thrombocytopenic purpura (TTP) or Moschowitz's syndrome is characterized by release of unusually large von Willebrand factor (ULvWF) multimers and a deficiency of vWF metalloprotease. It is a very rare condition, but it causes serious problems. The etiology is still unknown, although surgical stress has been associated with TTP, probably by releasing massive amounts of ULvWF. TTP is an acute, recurrent disease of the circulatory system, consisting of thrombocytopenia, microangiopathic hemolytic anemia, fever, neurological signs, and renal dysfunction. It has the strong possibility of being fatal and thus should be treated immediately, mostly by plasmapheresis. We report a case of TTP following a high tibial valgus osteotomy. An association between TTP and orthopedic surgery--as far as we know--has only once been reported in the literature. We suggest that orthopedic surgeons should be aware of this because, although very rare, postsurgical TTP could be a life-threatening postoperative complication, which needs prompt diagnosis and treatment. |
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Authors:
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Michael I Iosifidis; Merkourios Ntavlis; Ioannis Giannoulis; Leonidas Malioufas; Antonios Ioannou; Georgios Giantsis |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2006-03-09 |
Journal Detail:
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Title: Archives of orthopaedic and trauma surgery Volume: 126 ISSN: 0936-8051 ISO Abbreviation: Arch Orthop Trauma Surg Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-26 Completed Date: 2007-02-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9011043 Medline TA: Arch Orthop Trauma Surg Country: Germany |
Other Details:
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Languages: eng Pagination: 335-8 Citation Subset: IM |
Affiliation:
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Orthopaedic Department, Naoussa General Hospital Naoussa, 21 Filiaton-Ikarou Str, 55438 Thessaloniki, Greece. iosfyl@med.auth.gr |
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Middle Aged Osteoarthritis, Knee / surgery* Osteotomy / adverse effects* Plasmapheresis* Purpura, Thrombotic Thrombocytopenic / etiology*, therapy* Tibia / surgery |
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