Document Detail

Acute thrombotic thrombocytopenic purpura following orthopedic surgery: a case report.
MedLine Citation:
PMID:  16525809     Owner:  NLM     Status:  MEDLINE    
Thrombotic thrombocytopenic purpura (TTP) or Moschowitz's syndrome is characterized by release of unusually large von Willebrand factor (ULvWF) multimers and a deficiency of vWF metalloprotease. It is a very rare condition, but it causes serious problems. The etiology is still unknown, although surgical stress has been associated with TTP, probably by releasing massive amounts of ULvWF. TTP is an acute, recurrent disease of the circulatory system, consisting of thrombocytopenia, microangiopathic hemolytic anemia, fever, neurological signs, and renal dysfunction. It has the strong possibility of being fatal and thus should be treated immediately, mostly by plasmapheresis. We report a case of TTP following a high tibial valgus osteotomy. An association between TTP and orthopedic surgery--as far as we know--has only once been reported in the literature. We suggest that orthopedic surgeons should be aware of this because, although very rare, postsurgical TTP could be a life-threatening postoperative complication, which needs prompt diagnosis and treatment.
Michael I Iosifidis; Merkourios Ntavlis; Ioannis Giannoulis; Leonidas Malioufas; Antonios Ioannou; Georgios Giantsis
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-03-09
Journal Detail:
Title:  Archives of orthopaedic and trauma surgery     Volume:  126     ISSN:  0936-8051     ISO Abbreviation:  Arch Orthop Trauma Surg     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-26     Completed Date:  2007-02-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9011043     Medline TA:  Arch Orthop Trauma Surg     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  335-8     Citation Subset:  IM    
Orthopaedic Department, Naoussa General Hospital Naoussa, 21 Filiaton-Ikarou Str, 55438 Thessaloniki, Greece.
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MeSH Terms
Middle Aged
Osteoarthritis, Knee / surgery*
Osteotomy / adverse effects*
Purpura, Thrombotic Thrombocytopenic / etiology*,  therapy*
Tibia / surgery

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