Document Detail

Acute thrombosis of Sorin tilting disc mitral prostheses.
MedLine Citation:
PMID:  6706439     Owner:  NLM     Status:  MEDLINE    
We observed four cases of prosthetic thrombosis in 77 patients who had had a tilting disc valve (Sorin model) inserted in the mitral position. In all cases, the clinical findings on admission consisted of congestive heart failure, absence of prosthetic closing click and mitral regurgitation murmur. M-mode and cross-sectional echocardiography were invariably diagnostic. Surgery was performed without delay and consisted of thrombectomy in one case and valve replacement with porcine xenograft in three. Examination of the explanted prostheses disclosed fibrous tissue overgrowth surrounding the valvular ring, as well as thrombotic vegetations on the ventricular and atrial sides. The disc appeared blocked in a semiopening position at an angle of 45 degrees. Our experience suggests that the thrombosis is secondary to disc malfunction itself produced by periannular tissue growth. It is related to the porosity of the fabric which surrounds the metal ring, the valve design and its orientation. Correct anticoagulation therapy, performed in all cases, had no significant effect on tissue overgrowth. The high postoperative mortality rate depended on the severity of the preoperative clinical condition of the patients.
L Agozzino; R Bellitti; S Schettini; M Cotrufo
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  5     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-05-18     Completed Date:  1984-05-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  351-9     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Equipment Failure
Heart Failure / etiology
Heart Valve Prosthesis / adverse effects*
Middle Aged
Mitral Valve / pathology
Mitral Valve Insufficiency / etiology
Prosthesis Design
Thrombosis / diagnosis,  etiology*,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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