Document Detail

Acute thermogenic effects of nicotine combined with caffeine during light physical activity in male and female smokers.
MedLine Citation:
PMID:  8074059     Owner:  NLM     Status:  MEDLINE    
The thermogenic effects of nicotine and caffeine during physical activity compared with rest were examined in male and female smokers (n = 10 each). During eight sessions, nicotine (15 micrograms/kg) or placebo was given via measured-dose nasal spray intermittently after consumption of decaffeinated coffee with or without added caffeine (5 mg/kg), followed by assessment of energy expenditure by indirect calorimetry while subjects engaged in standardized, low-intensity cycle ergometer riding (activity) or remained at quiet rest. Results indicated significant thermogenic effects of nicotine and caffeine individually, with the combination of nicotine and caffeine producing additive effects. Expenditure attributable to nicotine, caffeine, or their combination was significantly enhanced during activity compared with rest, but only for males and not females. Plasma nicotine concentrations were influenced by activity and caffeine, but these pharmacokinetic changes did not appear to explain the differences in expenditure. These findings suggest a sex difference in thermogenic effects of nicotine and caffeine during casual physical activity and potentially explain some of the apparent individual variability in expenditure due to tobacco smoking.
K A Perkins; J E Sexton; L H Epstein; A DiMarco; C Fonte; R L Stiller; A Scierka; R G Jacob
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  60     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1994-09-29     Completed Date:  1994-09-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  312-9     Citation Subset:  AIM; IM    
Department of Psychiatry and Anesthesiology, University of Pittsburgh School of Medicine, PA 15213.
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MeSH Terms
Administration, Intranasal
Caffeine / administration & dosage,  blood,  pharmacology*
Calorimetry, Indirect
Chromatography, Gas
Drug Interactions
Energy Metabolism / drug effects*
Exercise / physiology*
Heart Rate / drug effects
Nicotine / administration & dosage,  blood,  pharmacology*
Sex Factors
Smoking / metabolism*
Grant Support
Reg. No./Substance:
0/Aerosols; 54-11-5/Nicotine; 58-08-2/Caffeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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