Document Detail

Acute testing of the rate-smoothed pacing algorithm for ventricular rate stabilization.
MedLine Citation:
PMID:  10234708     Owner:  NLM     Status:  MEDLINE    
We evaluated the capability of a new pacemaker-based rate-smoothing algorithm (RSA) to reduce the irregular ventricular response of AF. RSA prevents sudden decreases in rate using a modified physiological band and flywheel feature. Twelve patients (51 +/- 21 years) with hemodynamically tolerated AF of 4 months to 20 years duration were studied. Atrial and ventricular leads were connected to the external pacemaker device in the electrophysiology laboratory. Consecutive RR intervals during AF were measured at baseline and after ventricular pacing with RSA ON. Ventricular pacing with the rate smoothing algorithm reduced maximum RR intervals (1,207 +/- 299 vs 855 +/- 148 ms, P = 0.0005), with no significant change in the minimum RR interval (401 +/- 55 vs 393 +/- 74 ms, P = 0.292). A small shortening of the mean RR interval (634 +/- 153 vs 594 +/- 135 ms, P = 0.007) was seen with no change in the median RR interval (609 +/- 153 vs 595 +/- 143 ms, P = 0.388). There was a 43% reduction in RR standard deviation (145 +/- 52 vs 82 +/- 28, P = 0.0005), 49% reduction in mean absolute RR interval difference (MAD) (152 +/- 64 vs 77 +/- 34, P = 0.0005) and MAD/mean RR ratio (0.23 +/- 0.05 vs 0.13 +/- 0.04, P = 0.0005). We conclude that rate-smoothed pacing effectively reduces RR variability of AF in the acute setting.
J K Lee; R Yee; M Braney; G Stoop; M Begemann; C Dunne; G J Klein; A D Krahn; N M Van Hemel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  22     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-06-18     Completed Date:  1999-06-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  554-61     Citation Subset:  IM    
London Health Sciences Centre, Ontario, Canada.
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MeSH Terms
Aged, 80 and over
Atrial Fibrillation / physiopathology,  therapy*
Cardiac Pacing, Artificial / methods*
Cohort Studies
Equipment Design
Heart Rate / physiology
Middle Aged
Pacemaker, Artificial*
Signal Processing, Computer-Assisted
Ventricular Function / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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