| Acute systemic anaphylaxis in adult domestic fowl--possible role of vasoactive lipids and peptides. | |
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MedLine Citation:
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PMID: 311623 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bovine albumin (BA: 2 mg/kg-1, i.v.) produced a fall in systemic arterial blood pressure accompanied by central venous hypertension and bradycardia in pentobarbital-anaesthetized, spontaneously breathing, bovine albumin-sensitized adult domestic fowl. Trasylol (a potent inhibitor of kallikreins) suppressed acute systemic anaphylaxis. Polyphloretin phosphate (an effective antagonist of PGF2alpha) also inhibited the cardiovascular responses to antigen and PGF2alpha. Sodium meclofenamate and phenylbutazone showed varying degree of blockade of cardiovascular responses to exogenously administered chemical mediators (bradykinik, PGF2alpha, SRS-A and to a lesser extent of histamine, 5-HT and acetylcholine) and antigen. Indomethacin (virtually devoid of receptor blocking activities toward exogenously injected chemical mediators) inhibited anaphylaxis. The results of this investigation strongly suggested an important role of vasoactive lipids and polypeptides in avian anaphylaxis. |
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Authors:
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N Chand; P Eyre |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archives internationales de pharmacodynamie et de thérapie Volume: 236 ISSN: 0003-9780 ISO Abbreviation: Arch Int Pharmacodyn Ther Publication Date: 1978 Nov |
Date Detail:
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Created Date: 1979-05-23 Completed Date: 1979-05-23 Revised Date: 2012-01-12 |
Medline Journal Info:
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Nlm Unique ID: 0405353 Medline TA: Arch Int Pharmacodyn Ther Country: BELGIUM |
Other Details:
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Languages: eng Pagination: 164-76 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anaphylaxis
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chemically induced,
physiopathology* Animals Aprotinin / pharmacology Biogenic Amines / physiology* Chickens Indomethacin / pharmacology Lipids / physiology* Meclofenamic Acid / pharmacology Peptides / physiology* Phenylbutazone / pharmacology Polyphloretin Phosphate / pharmacology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Biogenic Amines; 0/Lipids; 0/Peptides; 50-33-9/Phenylbutazone; 53-86-1/Indomethacin; 644-62-2/Meclofenamic Acid; 9014-72-6/Polyphloretin Phosphate; 9087-70-1/Aprotinin |
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