| Acute supplementation with keto analogues and amino acids in rats during resistance exercise. | |
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MedLine Citation:
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PMID: 20594391 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During exercise, ammonia levels are related to the appearance of both central and peripheral fatigue. Therefore, controlling the increase in ammonia levels is an important strategy in ameliorating the metabolic response to exercise and in improving athletic performance. Free amino acids can be used as substrates for ATP synthesis that produces ammonia as a side product. Keto analogues act in an opposite way, being used to synthesise amino acids whilst decreasing free ammonia in the blood. Adult male rats were divided into four groups based on receiving either keto analogues associated with amino acids (KAAA) or a placebo and resistance exercise or no exercise. There was an approximately 40% increase in ammonaemia due to KAAA supplementation in resting animals. Exercise increased ammonia levels twofold with respect to the control, with a smaller increase (about 20%) in ammonia levels due to exercise. Exercise itself causes a significant increase in blood urea levels (17%). However, KAAA reduced blood urea levels to 75% of the pre-exercise values. Blood urate levels increased 28% in the KAAA group, independent of exercise. Supplementation increased glucose levels by 10% compared with control animals. Exercise did not change glucose levels in either the control or supplemented groups. Exercise promoted a 57% increase in lactate levels in the control group. Supplementation promoted a twofold exercise-induced increase in blood lactate levels. The present results suggest that an acute supplementation of KAAA can decrease hyperammonaemia induced by exercise. |
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Authors:
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Rosemeire Dantas de Almeida; Eduardo Seixas Prado; Carlos Daniel Llosa; Anibal Magalhães-Neto; Luiz-Claudio Cameron |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-02 |
Journal Detail:
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Title: The British journal of nutrition Volume: 104 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-10 Completed Date: 2010-12-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 1438-42 Citation Subset: IM |
Affiliation:
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Laboratory of Protein Biochemistry, Federal University of State of Rio de Janeiro, Av. Pasteur, 296, Urca, Rio de Janeiro, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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administration & dosage,
pharmacology* Animal Feed Animal Nutritional Physiological Phenomena Animals Diet Dietary Supplements Hyperammonemia Keto Acids / administration & dosage, chemistry*, pharmacology* Lactic Acid / blood Male Motor Activity / physiology* Physical Conditioning, Animal / physiology* Rats Rats, Wistar Uric Acid / blood |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Keto Acids; 50-21-5/Lactic Acid; 69-93-2/Uric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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