| Acute, subacute and subchronic safety assessment of betalains rich Rivina humilis L. berry juice in rats. | |
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MedLine Citation:
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PMID: 21914457 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Rivina humilis L. (Phytolaccaceae) accumulates vacuolar pigments betalains. These pigments are synthesized by plants of 11 families in the order caryophyllales. Red beet is the only industrial source of these hydrophilic and low acidic pigments. Betalains rich R. humilis berry juice (RBJ) could be used as alternative source of these pigments. However, there is no information on safety of these berries. In this research work, RBJ was fed to adult (single-dose: 1, 2 and 5g RBJ/kg bw) and growing (repeated-dosing: 2.5 and 5g RBJ/kg bw for 35days; dietary feeding: 0.5%, 1% and 2% RBJ in diet, w/w for 90days) male rats to assess acute, subacute and subchronic toxic responses. In all the three studies, RBJ was well tolerated plus the feed intake, body and organ weights of RBJ administered groups were comparable to that of untreated control rats. Data on hematology, histology of vital organs, biochemical measurements in serum and liver of RBJ treated rats were comparable to that of control in repeated-dosing and subchronic dietary study. These results suggest that intake of RBJ does not affect growth and normal biochemical homeostasis. Hence, RBJ is safe to consume without any adverse effects in the body. |
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Authors:
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Mohammad Imtiyaj Khan; K M Denny Joseph; Muralidhara; H P Ramesh; P Giridhar; G A Ravishankar |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-5 |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: - ISSN: 1873-6351 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
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Plant Cell Biotechnology Department, Central Food Technological Research Institute (A Constituent Laboratory of Council for Scientific and Industrial Research, New Delhi), Mysore 570 020, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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