| Acute stroke thrombolysis: time to dispense with the clock and move to tissue-based decision making? | |
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MedLine Citation:
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PMID: 21517729 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Currently, imaging is predominantly used to exclude patients for thrombolysis, rather than identify patients most likely to benefit. This means that patients are being selected for treatment without reference to tissue pathophysiology. Imaging of specific stroke pathophysiology may be the key to selecting patients most likely to benefit from thrombolysis, and could revolutionize acute stroke assessment and treatment. The technology is available to identify the acute infarct core and possibly the penumbra, via magnetic resonance diffusion-weighted imaging, and both magnetic resonance- and computed tomography-perfusion imaging techniques. However, these modalities require fine tuning before they can be reliably implemented in a routine clinical setting. |
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Authors:
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Andrew Bivard; Neil Spratt; Christopher R Levi; Mark W Parsons |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert review of cardiovascular therapy Volume: 9 ISSN: 1744-8344 ISO Abbreviation: Expert Rev Cardiovasc Ther Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101182328 Medline TA: Expert Rev Cardiovasc Ther Country: England |
Other Details:
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Languages: eng Pagination: 451-61 Citation Subset: IM |
Affiliation:
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Department of Neurology and Hunter Medical Research Institute (MWP, CRL), John Hunter Hospital, University of Newcastle, NSW 2305, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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