Document Detail


Acute stress differentially affects corticotropin-releasing hormone mRNA expression in the central amygdala of the "depressed" flinders sensitive line and the control flinders resistant line rats.
MedLine Citation:
PMID:  18077069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Preclinical and clinical evidence suggests that neuropeptides play a role in the pathophysiology of mood disorders. In the present study, we investigated the involvement of the peptides corticotropin-releasing hormone (CRH), neuropeptide Y (NPY) and nociceptin/orphanin FQ (N/OFQ) and of their receptors in the regulation of emotional behaviours. In situ hybridization experiments were performed in order to evaluate the mRNA expression levels of these neuropeptidergic systems in limbic and limbic-related brain regions of the Flinders Sensitive Line (FSL) rats, a putative genetic animal model of depression. The FSL and their controls, the Flinders Resistant Line (FRL) rats, were subjected to one hour acute restraint and the effects of the stress exposure, including possible strain specific changes on these neuropeptidergic systems, were studied. In basal conditions, no significant differences between FSL and FRL rats in the CRH mRNA expression were found, however an upregulation of the CRH mRNA hybridization signal was detected in the central amygdala of the stressed FRL, compared to the non stressed FRL rats, but not in the FSL, suggesting a hypoactive mechanism of response to stressful stimuli in the "depressed" FSL rats. Baseline levels of NPY and N/OFQ mRNA were lower in the FSL rats compared to the FRL in the dentate gyrus of hippocampus and in the medial amygdala, respectively. However, the exposure to stress induced a significant upregulation of the N/OFQ mRNA levels in the paraventricular thalamic nucleus, while in the same nucleus the N/OFQ receptor mRNA expression was higher in the FSL rats. In conclusion, selective alterations of the NPY and N/OFQ mRNA in limbic and limbic-related regions of the FSL rats, a putative animal model of depression, provide further support for the involvement of these neuropeptides in depressive disorders. Moreover, the lack of CRH activation following stress in the "depressed" FSL rats suggests a form of allostatic load, that could alter their interpretation of environmental stimuli and influence their behavioural response to stressful situations.
Authors:
Erika Zambello; Patricia A Jiménez-Vasquez; Aram El Khoury; Aleksander A Mathé; Laura Caberlotto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-17
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  32     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-05     Completed Date:  2008-07-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  651-61     Citation Subset:  IM    
Affiliation:
Section of Pharmacology, Department of Medicine and Public Health, University of Verona, Italy. erika.2.zambello@gsk.com
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MeSH Terms
Descriptor/Qualifier:
Amygdala / metabolism*
Animals
Corticotropin-Releasing Hormone / genetics*
Depression / genetics,  metabolism*,  physiopathology
Disease Models, Animal
Gene Expression Regulation / physiology*
Male
Opioid Peptides / genetics,  metabolism
RNA, Messenger / metabolism*
Rats
Rats, Inbred Strains
Receptors, Neuropeptide Y / genetics,  metabolism
Receptors, Opioid / genetics,  metabolism
Stress, Psychological / genetics,  pathology,  physiopathology*
Chemical
Reg. No./Substance:
0/Opioid Peptides; 0/RNA, Messenger; 0/Receptors, Neuropeptide Y; 0/Receptors, Opioid; 0/nociceptin; 0/nociceptin receptor; 9015-71-8/Corticotropin-Releasing Hormone

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