| Acute stent thrombosis in a patient with giant cell arteritis. | |
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MedLine Citation:
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PMID: 18401478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 70-year-old man presented with a non-ST elevation myocardial infarction attributable to a 99% occlusion of his mid-left anterior descending artery and concomitant symptoms suggestive of giant cell arteritis. He underwent bare metal stenting, with an excellent angiographic result, and was placed on dual antiplatelet therapy, as well as oral prednisone 30 mg twice daily, while awaiting confirmatory temporal artery biopsy. Unfortunately, 70 h after percutaneous coronary intervention, he developed acute stent thrombosis. Platelet aggregometry demonstrated that he was responsive to acetylsalicylic acid, but marginally responsive to clopidogrel. Over the next 30 days, he had a marked clinical improvement, with an improvement in platelet response to clopidogrel that paralleled the clinical resolution of his vasculitis. The present case reports the first incidence of acute stent thrombosis associated with giant cell arteritis, and suggests that the proinflammatory milieu of acute inflammatory arthritides may warrant prolonged, aggressive antiplatelet therapy in the setting of an acute coronary syndrome. |
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Authors:
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Jason Andrade; Abdullah Al Ali; Jacqueline Saw; Graham C Wong |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Canadian journal of cardiology Volume: 24 ISSN: 1916-7075 ISO Abbreviation: Can J Cardiol Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-10 Completed Date: 2008-05-05 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 8510280 Medline TA: Can J Cardiol Country: Canada |
Other Details:
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Languages: eng Pagination: e25-6 Citation Subset: IM |
Affiliation:
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Division of Cardiology, University of British Columbia, Vancouver General Hospital, Vancouver. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Transluminal, Percutaneous Coronary* Aspirin / therapeutic use Coronary Angiography Coronary Artery Disease / diagnosis*, drug therapy Coronary Thrombosis / diagnosis*, drug therapy Giant Cell Arteritis / diagnosis*, drug therapy Humans Male Myocardial Infarction / therapy* Platelet Aggregation Inhibitors / therapeutic use Prednisone / therapeutic use Stents* Ticlopidine / analogs & derivatives, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin; 53-03-2/Prednisone; 55142-85-3/Ticlopidine; 90055-48-4/clopidogrel |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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