Document Detail

Acute severe reversible oligohydramnios induced by indomethacin in a patient with rheumatoid arthritis: a case report and review of the literature.
MedLine Citation:
PMID:  14998195     Owner:  NLM     Status:  MEDLINE    
Although the association between oligohydramnios and indomethacin use for premature labor has been well known for many years, there have been few cases published about it. We present a case of indomethacin-induced oligohydramnios due to use in a patient for rheumatoid arthritis. A 27-year-old G2P1 woman was referred to our prenatal unit with oligohydramnios at 33 weeks of pregnancy. Ultrasonography revealed severe oligohydramnios with an amniotic fluid index of 0.9 cm. She gave a history of daily 150 mg indomethacin use for newly diagnosed rheumatoid arthritis. All possible reasons for oligohydramnios were excluded and indomethacin was discontinued. In four days the amniotic fluid was observed as normal. We concluded that the oligohydramnios caused by indomethacin occurs quickly, is dose-related and reversible. Amniotic fluid volume should be monitored while using indomethacin.
S Topuz; R Has; H Ermiş; A Yildirim; L Ibrahimoğlu; A Yüksel
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical and experimental obstetrics & gynecology     Volume:  31     ISSN:  0390-6663     ISO Abbreviation:  Clin Exp Obstet Gynecol     Publication Date:  2004  
Date Detail:
Created Date:  2004-03-04     Completed Date:  2004-04-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802110     Medline TA:  Clin Exp Obstet Gynecol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  70-2     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Istanbul University, School of Medicine, Istanbul, Turkey.
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MeSH Terms
Acute Disease
Arthritis, Rheumatoid / drug therapy*
Cyclooxygenase Inhibitors / adverse effects*
Indomethacin / adverse effects*
Oligohydramnios / chemically induced*
Pregnancy Complications / drug therapy*
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 53-86-1/Indomethacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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