Document Detail

Acute schistosomiasis, a diagnostic and therapeutic challenge.
MedLine Citation:
PMID:  20222897     Owner:  NLM     Status:  MEDLINE    
In non-endemic countries, acute (invasive) schistosomiasis (AS) is typically seen in non-immune travellers, whereas chronic schistosomiasis is more frequently diagnosed in immigrants. Travellers with AS initially present with non-specific signs such as fever, cough, headache, and urticaria. Life-threatening cardiac and neurological complications may occur. The positive diagnosis of AS relies on seroconversion, which appears together with hypereosinophilia approximately 3 weeks after the onset of symptoms. When prescribed during AS, praziquantel usually does not prevent the chronic phase of the disease and is associated with exacerbation of signs and symptoms in approximately 50% of cases. According to the published literature, corticosteroids may be recommended alone or in association with praziquantel. When associated with corticosteroids, pharmacokinetic interactions may impair the efficacy of praziquantel. We suggest that corticosteroids should be restricted to use in patients with systemic complications of AS, whereas praziquantel should be initiated only when ova are detected in either stools or urine, depending on the culprit species.
S Jaur?guiberry; L Paris; E Caumes
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases     Volume:  16     ISSN:  1469-0691     ISO Abbreviation:  Clin. Microbiol. Infect.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-12     Completed Date:  2010-05-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9516420     Medline TA:  Clin Microbiol Infect     Country:  France    
Other Details:
Languages:  eng     Pagination:  225-31     Citation Subset:  IM    
Department of Infectious, Tropical Diseases and Parasitology-Mycology, Groupe Hospitalier Piti? Salp?tri?re, Assistance Publique des H?pitaux de Paris, Paris, France.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Antibodies, Protozoan / blood
Antiprotozoal Agents / therapeutic use
Drug Interactions
Immunologic Factors / therapeutic use
Praziquantel / therapeutic use
Schistosomiasis / diagnosis*,  drug therapy*,  pathology
Serologic Tests
Time Factors
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Antibodies, Protozoan; 0/Antiprotozoal Agents; 0/Immunologic Factors; 55268-74-1/Praziquantel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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