| Acute dopamine/norepinephrine reuptake inhibition increases brain and core temperature in rats. | |
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MedLine Citation:
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PMID: 15920099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of the present study was to examine the effects of an acute dose of the dual dopamine (DA) and norepinephrine (NE) reuptake inhibitor bupropion (Bup) on brain (T(brain)), body core (T(core)), and tail skin (T(tail)) temperature in freely moving rats and to simultaneously monitor the extracellular neurotransmitter concentrations in the preoptic area and anterior hypothalamus (PO/AH). A microdialysis probe was inserted in the PO/AH, and samples for NE, DA, and serotonin (5-HT) were collected every 20 min before and after the injection of 17 mg/kg of Bup, for a total sampling time of 180 min. T(core) was monitored using a biotelemetry system. T(brain) and T(tail), an index of heat loss response, were also measured. Both NE and DA levels in the PO/AH significantly increased after Bup injection compared with the baseline levels, reaching approximately 450 and 230%, respectively, 40 min after injection. There was no effect on 5-HT release. The neurotransmitter changes were accompanied by a significant decrease in T(tail) and an increase in both T(brain) and T(core) compared with the baseline levels. The present results demonstrate that inhibition of NE and DA reuptake suppresses heat loss mechanisms and elevates T(brain) and T(core) in freely moving rats. |
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Authors:
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Hiroshi Hasegawa; Romain Meeusen; Sophie Sarre; Marc Diltoer; Maria Francesca Piacentini; Yvette Michotte |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-05-26 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 99 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-09-14 Completed Date: 2005-12-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 1397-401 Citation Subset: IM |
Affiliation:
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Department of Human Physiology and Sportsmedicine, Vrije Universiteit Brussel, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature / drug effects* Brain / drug effects, metabolism, physiology* Bupropion / administration & dosage, pharmacology* Dopamine / metabolism Dopamine Uptake Inhibitors / pharmacology* Extracellular Fluid / metabolism Hypothalamus, Anterior / metabolism Injections, Intraperitoneal Male Microdialysis Neurotransmitter Uptake Inhibitors / pharmacology* Norepinephrine / metabolism, physiology* Osmolar Concentration Preoptic Area / metabolism Rats Rats, Wistar Skin Temperature / drug effects Tail Telemetry |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Uptake Inhibitors; 0/Neurotransmitter Uptake Inhibitors; 34841-39-9/Bupropion; 51-41-2/Norepinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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