| Acute responses to urapidil in hypertensive persons. | |
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MedLine Citation:
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PMID: 2667310 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Urapidil is a new antihypertensive agent involving both a peripheral and a central mode of action. To evaluate the acute effects of this drug on renal vascular tone and on pressor systems a randomized placebo-controlled crossover study was conducted in 10 patients with uncomplicated essential hypertension. Each subject received, on 2 separate days 1 week apart, an intravenous injection of either placebo or urapidil (25 or, if necessary, 50 mg). Before and after this injection blood pressure and heart rate (Dinamap), renal plasma flow (125I-hippuran), active plasma renin concentration, angiotensin II, aldosterone and catecholamines in plasma were measured. The results show that urapidil, when compared with placebo, greatly reduced blood pressure, while increasing heart rate, renal blood flow, and noradrenaline and adrenaline levels. However, dopamine levels were suppressed. Whereas renin and angiotensin II were only mildly stimulated, aldosterone levels increased significantly. It is concluded that urapidil, given intravenously, has an immediate blood pressure-lowering effect associated with a decrease in renal vascular tone and an increase in renal perfusion. Consequently, both the sympathetic and renin-angiotensin systems are stimulated, although the latter only to a mild degree. The increase in aldosterone may be partially related to the decrease in dopamine levels. |
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Authors:
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P W de Leeuw; W H Birkenhäger |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The American journal of cardiology Volume: 64 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1989 Aug |
Date Detail:
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Created Date: 1989-09-05 Completed Date: 1989-09-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 22D-24D Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Zuiderziekenhuis, Rotterdam, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antihypertensive Agents / administration & dosage, therapeutic use* Blood Pressure / drug effects Catecholamines / blood Clinical Trials as Topic Double-Blind Method Female Heart Rate / drug effects Humans Hypertension / blood, drug therapy* Injections, Intravenous Male Middle Aged Piperazines / administration & dosage, therapeutic use* Random Allocation Renal Circulation / drug effects Renin-Angiotensin System / drug effects Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Catecholamines; 0/Piperazines; 34661-75-1/urapidil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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