| Acute respiratory distress syndrome as an initial presentation of hemophagocytic lymphohistiocytosis after induction therapy for acute myeloid leukemia. | |
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MedLine Citation:
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PMID: 21083362 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A 7-month-old girl with acute myeloid leukemia (AML) developed acute respiratory distress syndrome (ARDS) during the pancytopenic period after induction chemotherapy. Respiratory failure did not improve despite intensive treatments. Eventually, hemophagocytic lymphohistiocytosis (HLH) was diagnosed based on hemophagocytosis in bone marrow, and high soluble interleukin-2 receptor (sIL-2R) and ferritin levels. Even after cyclosporin A was started against HLH, she did not recover. Autopsy showed macrophage proliferation in bone marrow and lymph nodes. HLH should be considered, even in the pancytopenic period after chemotherapy, when patients develop ARDS that does not respond to supportive therapies. |
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Authors:
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Takuro Nishikawa; Yasuhiro Okamoto; Takayuki Tanabe; Yuichi Shinkoda; Yuichi Kodama; Yasuyuki Kakihana; Masamichi Goto; Yoshifumi Kawano |
Publication Detail:
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Type: Journal Article Date: 2010-11-17 |
Journal Detail:
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Title: Pediatric hematology and oncology Volume: 28 ISSN: 1521-0669 ISO Abbreviation: Pediatr Hematol Oncol Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8700164 Medline TA: Pediatr Hematol Oncol Country: England |
Other Details:
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Languages: eng Pagination: 244-8 Citation Subset: IM |
Affiliation:
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1Department of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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