Document Detail

Acute resistance exercise does not change the hormonal response to sublingual androstenediol intake.
MedLine Citation:
PMID:  16636857     Owner:  NLM     Status:  MEDLINE    
Sublingual intake of 21.4 mg androstenediol increases serum testosterone concentrations whereas swallowing 200 mg androstenediol does not. The duration of increase in serum testosterone following sublingual androstenediol (SL-DIOL) is unknown. Resistance exercise (EX) following SL-DIOL may cause larger increases in serum estradiol concentrations than while at rest. This project evaluated the duration of change in, and the effects of acute EX on, the hormonal response to SL-DIOL. Six young resistance trained males consumed either placebo (PL) or SL-DIOL before a single session of EX or no exercise (Rest) in a random, double blind, crossover manner (for a total of four trials). Blood samples were collected before supplementation, and at 60, 120, 180, 240, 480, and 720 min post-supplementation, with the exercise occurring between 60 and 120 min. The serum [total testosterone] increased (P < 0.05) at 60 min similarly in SL-DIOL-EX and SL-DIOL-Rest by approximately 115%, and at 120 min by approximately 107% with no differences due to exercise. The serum [estradiol] increased (P < 0.05) similarly in SL-DIOL-EX and SL-DIOL-Rest by approximately 33% at 60 min and approximately 45% at 120 min, with no differences due to exercise. Serum [testosterone] returned to baseline by 240 min and serum [estradiol] returned to baseline by 720 min post-intake. These findings indicate that SL-DIOL acutely elevates serum testosterone and estradiol concentrations, that EX does not alter the endocrine response to SL-DIOL, and that the increases in serum estradiol last between 480 and 720 min while the increases in serum testosterone last <240 min following acute SL-DIOL intake.
Gregory A Brown; Drew McKenzie
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2006-04-25
Journal Detail:
Title:  European journal of applied physiology     Volume:  97     ISSN:  1439-6319     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-28     Completed Date:  2006-09-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  404-12     Citation Subset:  IM    
Human Performance Laboratory, HPERLS Department, The University of Nebraska at Kearney, 68849, USA.
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MeSH Terms
Administration, Sublingual
Anabolic Agents / administration & dosage*
Androstenediol / administration & dosage*
Androstenedione / blood*
Doping in Sports*
Energy Intake
Estradiol / blood*
Exercise / physiology*
Testosterone / blood*
Time Factors
Reg. No./Substance:
0/Anabolic Agents; 50-28-2/Estradiol; 521-17-5/Androstenediol; 58-22-0/Testosterone; 63-05-8/Androstenedione

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